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M. J. Perez Carrasco, A. R. Barrio, C. Palomo, M. Muñoz, D. Rios, R. Sanchez, C. Puell; Assessment of Macular Pigment Optical Density: Metropsis Versus Macuscope. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4955.
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© ARVO (1962-2015); The Authors (2016-present)
To compare macular pigment optical density using two new different heterochromatic flicker photometer devices.
We measured macular pigment (MP) optical density at the fovea in 40 healthy young subjects using a screening non-invasive minimum flicker photometer device (Macuscope, Macuvision Europe, LTD) and the Metropsis test (Cambridge Research Systems) that is based in the apparent motion photometry method and employs a CRT monitor for stimulus presentation.
The mean macular pigment optical density measured using the Macuscope was 0.438 ± 0.17, and that using the Metropsis was 0.396 ± 0.14. The 95% confidence interval for the mean difference was 0.024 to 0.108. We found a significant correlation (Pearson’s correlation= 0.39; p< 0.0125) between Macuscope and Metropsis systems (PMmetropsis = 0.25 + 0.32 x PM macuscope; R2 = 15.31).
As the 95% confidence interval for the mean difference contains 0, we conclude that there is, on average, no significant difference in measurements provided by these two new devices. The Metropsis test tends to underestimate macular pigment compared with the Macuscope.
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