May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
A Pilot Study on the Effect of Lutein and Zeaxanthin Supplementation on Psychophysical and Electrophysiological Macular Outcome Measures
Author Affiliations & Notes
  • J. T. Armstrong
    Ophthalmology/Hamilton Eye Institute, Univ. TN Health Sci. Ctr., Memphis, Tennessee
    Christian Brothers University, Memphis, Tennessee
  • A. M. Deaton-Cantrell
    Ophthalmology/Hamilton Eye Institute, Univ. TN Health Sci. Ctr., Memphis, Tennessee
  • A. Iannaccone
    Ophthalmology/Hamilton Eye Institute, Univ. TN Health Sci. Ctr., Memphis, Tennessee
  • Footnotes
    Commercial Relationships  J.T. Armstrong, None; A.M. Deaton-Cantrell, None; A. Iannaccone, None.
  • Footnotes
    Support  NIH K23 EY000409 (AI), RPB (unrestricted grant to UTHSC HEI and CDA to AI); IRRF (AI); UTHSC Neuroscience Pre-Science Program (JTA)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4964. doi:https://doi.org/
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    • Get Citation

      J. T. Armstrong, A. M. Deaton-Cantrell, A. Iannaccone; A Pilot Study on the Effect of Lutein and Zeaxanthin Supplementation on Psychophysical and Electrophysiological Macular Outcome Measures. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4964. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
Abstract

Purpose: : Macular pigment optical density (MPOD) correlates strongly with glare resistance [Stringham, Optom. Vis. Sci. 2007; 84: 859-64] and weakly to faster glare recovery (GR) [Pratt 2002; ARVO E-Abstract 2540] in healthy subjects. Lutein (L) supplementation leads to improved GR in patients with age-related maculopathy [Richer 2003; ARVO E-Abstract 2540]. Furthermore, L supplementation correlates with improved pattern electroretinogram (PERG) amplitudes [Falsini, Ophthalmology 2003; 110:51-60], but its correlation to MPOD changes is not known. To our knowledge, neither the effects of L supplementation, nor those of L and zeaxanthin (Z) on other outcome measures of macular function have yet been studied. Therefore, the purpose of this study was to generate pilot data about the effects of L&Z supplementation on dark-adapted (DA) thresholds and recovery kinetics, pattern visual evoked potentials (PVEPs) before and after photo-stress, and PERG amplitude.

Methods: : A White, male, 21-year old healthy subject participated in this experiment. The MPOD profile was measured with a previously reported instrument and protocol [Iannaccone et al. IOVS 2007; 8:1458-65] at 0.25, 0.5, 1 and 2 degs of eccentricity. The PERG P50 component was measured in response to 45-min arc checks alternating at 2Hz. The timing of the P100 component of the photo-stress PVEP was measured before, and its recovery to baseline (BL) values was measured at 15-sec blocks in response to a 22- and 11-min arc, 6.25-deg radius, circular stimulus after a full bleach (7.47 log scot td s, estimated to achieve a 97% rhodopsin bleach). Foveal DA thresholds before a bleach (same as above), and cone DA recovery kinetics (to cone plateau) after the bleach were measured in response to a 650nm DA stimulus. All measurements were obtained at BL, and the after 4 months of daily dietary supplementation with 20mg L and 0.9mg Z (Lutein caps, VitaminShoppe, North Bergen, NJ).

Results: : Following L&Z supplementation, MPOD increased in each eye at all loci (mean MPOD: OD/OS BL: 0.26/0.28; OD/OS post-L&Z: 0.35/0.37; p = 0.004). These changes were accompanied by an increase in PERG P50 amplitude, as predicted by the study of Falsini et al., and by an increase in 650nm DA sensitivity (BL: 30dB; post-L&Z: 37dB), but no change in the cone recovery kinetics following the bleach or on photostress PVEP P100 recovery.

Conclusions: : L&Z supplementation can result in improved macular function also in healthy eyes by both electrophysiological and psychophysical criteria.

Keywords: macula/fovea • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • electroretinography: clinical 
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