May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Macular Pigment Optical Density, C-Reactive Protein, and Serum Lutein and Zeaxanthin in the Elderly
Author Affiliations & Notes
  • A. Iannaccone
    Univ. TN Health Sci. Ctr., Memphis, Tennessee
    Ophthalmology/Hamilton Eye Institute,
  • E. J. Johnson
    J. Mayer USDA Hum. Nutr. Res. Ctr. on Aging, Tufts Univ., Boston, Massachusetts
  • J. T. Armstrong
    Univ. TN Health Sci. Ctr., Memphis, Tennessee
    Ophthalmology/Hamilton Eye Institute,
    Christian Brothers University, Memphis, Tennessee
  • E. Kenyon
    Epidemiol. & Biostat., UCSF, San Francisco, California
  • T. Harris
    5NIA, NIH, Bethesda, Maryland
  • S. Satterfield
    Univ. TN Health Sci. Ctr., Memphis, Tennessee
    Preventive Medicine,
  • K. C. Johnson
    Univ. TN Health Sci. Ctr., Memphis, Tennessee
    Preventive Medicine,
  • S. B. Kritchevsky
    Univ. TN Health Sci. Ctr., Memphis, Tennessee
    Preventive Medicine,
    Sticht Ctr. on Aging, Wake Forest Univ., Winston-Salem, North Carolina
  • Footnotes
    Commercial Relationships  A. Iannaccone, None; E.J. Johnson, None; J.T. Armstrong, None; E. Kenyon, None; T. Harris, None; S. Satterfield, None; K.C. Johnson, None; S.B. Kritchevsky, None.
  • Footnotes
    Support  NIH K23 EY000409, N01 AG62101, N01 AG62103, N01 AG62106, IRRF; RPB; AHAF; UTHSC Neurosci. Pre-Science Progr.; DSM; Bausch & Lomb; Kemin Foods
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 4965. doi:https://doi.org/
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    • Get Citation

      A. Iannaccone, E. J. Johnson, J. T. Armstrong, E. Kenyon, T. Harris, S. Satterfield, K. C. Johnson, S. B. Kritchevsky; Macular Pigment Optical Density, C-Reactive Protein, and Serum Lutein and Zeaxanthin in the Elderly. Invest. Ophthalmol. Vis. Sci. 2008;49(13):4965. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report the relationship between macular pigment optical density (MPOD), C-reactive protein (CRP), and serum levels of lutein and zeaxanthin (L&Z) in elderly subjects.

Methods: : We studied 249 subjects participating in ARMA, an ancillary study to Health ABC [mean age +/- SD: 78.8 +/- 3.3 yo, 84% White, 55% females, 37% lutein supplement users (LSUs)], inclusive of both subjects with and without age-related maculopathy (ARM), since we have shown that having ARM does not per se affect MPOD [Iannaccone 2007; ARVO E-Abstract 2147]. MPOD estimates were obtained with a previously reported instrument and protocol [Iannaccone et al. IOVS 2007; 8: 1458-65] at 0.5 degrees of eccentricity from the fovea. Fasting serum samples were collected at time of visit and analyzed according to standardized protocols. L&Z and CRP were not normally distributed and were, therefore, ln-transformed.

Results: : Serum ln(L&Z) levels were strongly correlated to MPOD. However, the correlation was mainly driven by the lowest and highest MPOD quartiles. Serum L&Z displayed no relationship with MPOD values within the inter-quartile range. Likewise, serum ln(CRP) levels displayed a strong inverse correlation with MPOD quartiles, but this relationship was mainly driven by the ln(CRP) levels in the first MPOD quartile. No correlation was present across the subsequent three MPOD quartiles. Lastly, consistent with data previously reported by our group [Kritchevsky et al. AJE 2000; 152: 1065-71; Gruber et al. J Nutr. 2004; 134: 2387-94], serum ln(L&Z) displayed a strong inverse correlation with ln(CRP) quartiles, showing a progressive but curvilinear decline of serum ln(L&Z) levels by ln(CRP) quartile. The relationship with serum ln(L&Z) across the top three ln(CRP) quartiles was much weaker.

Conclusions: : In elderly individuals, MPOD, ln(L&Z) and ln(CRP) are strongly correlated to one another. However, the relationship is complex and not linear across quartiles. These findings provide an explanation for the variable findings from previous reports, indicate that studies on these variables are likely to show different degrees of correlation between them depending on the range of MPOD, ln(L&Z), and ln(CRP) of the population sample examined, and help us gain insights on the effect of serological variables on the biology of retinal carotenoids.

Keywords: clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology • carotenoids/carotenoid binding proteins • inflammation 
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