May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Diagnosing and Monitoring Corneo-Conjunctival Ocular Surface Squamous Tumors: An in vivo Confocal Microscopy Approach
Author Affiliations & Notes
  • R. Parrozzani
    Ophthalmology, University of Padova, Padova, Italy
  • S. Miotto
    Ophthalmology, University of Padova, Padova, Italy
  • M. Cortese
    Ophthalmology, University of Padova, Padova, Italy
  • M. Gurabardhi
    Ophthalmology, University of Padova, Padova, Italy
  • V. De Belvis
    Ophthalmology, University of Padova, Padova, Italy
  • E. Midena
    Ophthalmology, University of Padova, Padova, Italy
    G.B. Bietti Eye Foundation, IRCCS, Roma, Italy
  • Footnotes
    Commercial Relationships  R. Parrozzani, None; S. Miotto, None; M. Cortese, None; M. Gurabardhi, None; V. De Belvis, None; E. Midena, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5014. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R. Parrozzani, S. Miotto, M. Cortese, M. Gurabardhi, V. De Belvis, E. Midena; Diagnosing and Monitoring Corneo-Conjunctival Ocular Surface Squamous Tumors: An in vivo Confocal Microscopy Approach. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5014. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To analyze Ocular Surface Squamous (OSS) tumors using clinical confocal microscopy and compare the in-vivo imaging with cytological aspect before and after treatment.

Methods: : Ten consecutive cases of OSS tumors were investigated at baseline and during follow-up using in-vivo clinical corneal and conjunctival confocal microscopy (Confoscan 4, Nidek). All tumors underwent topical chemotherapy with 1% 5-FU four times daily for 4 weeks (one course). Baseline and follow-up data obtained with confocal microscopy were compared to cytologic samples obtained by scraping technique. Follow-up was longer than 12 months.

Results: : Mean follow-up was 18±3 months. Baseline confocal microscopy analysis of OSS tumors showed good agreement with correspondent cytologic tumor aspect and reveals some structural-histologic characteristics of the lesions. All patients showed clinical regression of OSS tumor after one course of topical 1% 5-FU treatment. Confocal microscopy analysis showed complete replacement of OSS neoplastic cell by normal epithelium within 4 months in 8 cases. Two cases showed persistent structural and corneo-conjunctival cytological abnormalities consistent with a suspect early recurrence or with just partial eradication of the lesion. These two patients underwent additional course of topical chemotherapy with complete clinically and confocal imaging eradication.

Conclusions: : In-vivo corneal and conjunctival confocal microscopy is a reliable non-invasive method to follow clinical and cyto-histologic aspect of OSS tumors, particularly when treated with topical chemotherapy.

Keywords: tumors • conjunctiva • imaging/image analysis: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×