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R. P. Nguyen, M. Pekmezci, T. Porco, D. S. Friedman, S. Lin; Assessment of Anterior Chamber Angles Using Anterior Segment Optical Coherence Tomography and Gonioscopy Across Ethnic Groups. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5082.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the effect of ethnicity on the correlation between OCT (optical coherence tomography) and gonioscopic measurements of the anterior chamber angle.
Four hundred sixteen eyes of 225 patients from an academic glaucoma clinic in San Francisco were included in this retrospective, cross-sectional study. Images of the temporal and nasal anterior chamber angles were obtained with the Visante AS-OCT in dark conditions and analyzed with UBM software for the ARA (angle recess area) and AOD500 (angle opening distance at 500µm). These parameters were compared with Shaffer grade in low lighting conditions.
The sample was comprised of 43% Asian, 10% Black, 11% Latino, 31% White, and 3% other. ARA and AOD500 were significant predictors of gonioscopic grade for the sample (P<0.001). Spearman correlation between ARA and gonioscopy grading for Asian, Black, Latino, and White patients were similar, with the largest correlations found in Asian and Black patients temporally (0.71, P<0.001) and Latino patients nasally (0.75, P<0.001). The smallest correlations were found in White patients (0.63 temporally, P<0.001); 0.68 nasally, P<0.001). Spearman correlations between AOD500 and gonioscopy grading were again largest in Asian and Black patients temporally (0.73, P<0.001) and Latino patients nasally (0.75, P<0.001). However, the smallest correlation was found in Latino patients temporally (0.59, P<0.001) and again White patients nasally(0.64, P<0.001). When using White patients as a reference group, evidence for a difference in the relationship between OCT parameters and gonioscopy grading was strongest in Asian patients temporally and nasally and in Latino patients nasally (P<0.001). Black patients and non-black patients differed in their relationship between nasal OCT parameters and gonioscopy grading (P<0.001) while White and non-White patients differed in their relationship between temporal OCT parameters and gonioscopy grading (P=0.027 ARA; P=0.023 AOD500).
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