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N. Amerasinghe, T.-Y. Wong, H. M. Htoon, S. M. Saw, S. Shen, H. T. Aung, T. Aung, The Singapore Malay Eye Study (SiMES); Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5083.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the variation of iridocorneal angle parameters in Malay adults in Singapore as measured by Anterior Segment Optical Coherence Tomography (AS-OCT)
This population based, cross-sectional study examined 3,280 (78.7% response rate) Malay people aged 40-80 years in Singapore. Participants had a standardized interview, ocular and systemic examination. AS-OCT was performed on 291 consecutive patients in standardized conditions. Angle opening distance 500 microns anterior to the scleral spur (AOD 500) and trabecular-iris space area 500 microns from the scleral spur (TISA 500) were determined for the nasal and temporal angles. Anterior chamber depth (ACD) was also determined.
AS-OCT measurements were analyzed in 239 (82.1% of 291) right eye images. Mean AOD 500 was smaller in females compared to males, both nasally, (0.2552 vs. 0.2928 mm, p=0.026) and temporally(0.2452 vs. 0.2855mm, p=0.023). Mean TISA 500 was smaller in females in the nasal quadrant only (0.1039 vs. 0.1171mm, p=0.035). Mean ACD was smaller in females (2.707 vs. 2.867mm, p=0.001). Adjusted multiple linear regression showed that increasing axial length and ACD were significant determinants of increasing AOD 500 both nasally (adjusted R2=0.339) and temporally (adjusted R2=0.345) as well as TISA 500 both nasally (adjusted R2=0.200) and temporally (adjusted R2=0.239). Body mass index, HbA1c, blood pressure, intraocular pressure, cup to disc ratio and central corneal thickness were not significantly associated with AOD 500, TISA 500 and ACD.
In this population-based study of Malays, all measures of anterior segment angles (AOD 500, TISA 500 and ACD) were smaller in females compared to males. Other significant determinants of AOD 500 and TISA 500 were axial length and ACD.
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