May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays
Author Affiliations & Notes
  • N. Amerasinghe
    Singapore National Eye Centre, Singapore, Singapore
  • T.-Y. Wong
    Singapore National Eye Centre, Singapore, Singapore
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • H. M. Htoon
    Singapore Eye Research Institute, Singapore, Singapore
  • S. M. Saw
    Singapore National Eye Centre, Singapore, Singapore
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • S. Shen
    Singapore National Eye Centre, Singapore, Singapore
  • H. T. Aung
    Singapore Eye Research Institute, Singapore, Singapore
  • T. Aung
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • The Singapore Malay Eye Study (SiMES)
    Singapore National Eye Centre, Singapore, Singapore
  • Footnotes
    Commercial Relationships  N. Amerasinghe, None; T. Wong, None; H.M. Htoon, None; S.M. Saw, None; S. Shen, None; H.T. Aung, None; T. Aung, Carl Zeiss Meditec, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, R.
  • Footnotes
    Support  National Medical Research Council Grants No 0796/2003, 0863/2004 and CSI/0002/2005, and Biomedical Research Council Grant No 501/1/25-5.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5083. doi:https://doi.org/
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      N. Amerasinghe, T.-Y. Wong, H. M. Htoon, S. M. Saw, S. Shen, H. T. Aung, T. Aung, The Singapore Malay Eye Study (SiMES); Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5083. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To describe the variation of iridocorneal angle parameters in Malay adults in Singapore as measured by Anterior Segment Optical Coherence Tomography (AS-OCT)

Methods: : This population based, cross-sectional study examined 3,280 (78.7% response rate) Malay people aged 40-80 years in Singapore. Participants had a standardized interview, ocular and systemic examination. AS-OCT was performed on 291 consecutive patients in standardized conditions. Angle opening distance 500 microns anterior to the scleral spur (AOD 500) and trabecular-iris space area 500 microns from the scleral spur (TISA 500) were determined for the nasal and temporal angles. Anterior chamber depth (ACD) was also determined.

Results: : AS-OCT measurements were analyzed in 239 (82.1% of 291) right eye images. Mean AOD 500 was smaller in females compared to males, both nasally, (0.2552 vs. 0.2928 mm, p=0.026) and temporally(0.2452 vs. 0.2855mm, p=0.023). Mean TISA 500 was smaller in females in the nasal quadrant only (0.1039 vs. 0.1171mm, p=0.035). Mean ACD was smaller in females (2.707 vs. 2.867mm, p=0.001). Adjusted multiple linear regression showed that increasing axial length and ACD were significant determinants of increasing AOD 500 both nasally (adjusted R2=0.339) and temporally (adjusted R2=0.345) as well as TISA 500 both nasally (adjusted R2=0.200) and temporally (adjusted R2=0.239). Body mass index, HbA1c, blood pressure, intraocular pressure, cup to disc ratio and central corneal thickness were not significantly associated with AOD 500, TISA 500 and ACD.

Conclusions: : In this population-based study of Malays, all measures of anterior segment angles (AOD 500, TISA 500 and ACD) were smaller in females compared to males. Other significant determinants of AOD 500 and TISA 500 were axial length and ACD.

Keywords: imaging/image analysis: clinical • clinical (human) or epidemiologic studies: systems/equipment/techniques • anterior segment 
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