May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Quantitative Analysis of the Anterior Chamber by Visante and Slit-Lamp Anterior Segment Optical Coherence Tomography
Author Affiliations & Notes
  • L. M. Sakata
    SERI, Singapore National Eye Centre, Singapore, Singapore
    UFPR, Curitiba, Brazil
  • H. Wong
    Tan Tock Seng Hospital, Singapore, Singapore
  • T. Wong
    SERI, Singapore National Eye Centre, Singapore, Singapore
  • R. Kumar
    SERI, Singapore National Eye Centre, Singapore, Singapore
  • H. Htoon
    SERI, Singapore National Eye Centre, Singapore, Singapore
  • H. Aung
    SERI, Singapore National Eye Centre, Singapore, Singapore
  • M. He
    Zhongshan Ophtalmic Center, Guangzhou, China
  • T. Aung
    SERI, Singapore National Eye Centre, Singapore, Singapore
  • Footnotes
    Commercial Relationships  L.M. Sakata, None; H. Wong, Carl-Zeiss Meditec, F; T. Wong, None; R. Kumar, None; H. Htoon, None; H. Aung, None; M. He, Carl-Zeiss Meditec, F; T. Aung, Carl-Zeiss Meditec, F; Carl-Zeiss Meditec, C; Carl-Zeiss Meditec, R.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5085. doi:https://doi.org/
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    • Get Citation

      L. M. Sakata, H. Wong, T. Wong, R. Kumar, H. Htoon, H. Aung, M. He, T. Aung; Quantitative Analysis of the Anterior Chamber by Visante and Slit-Lamp Anterior Segment Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5085. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To compare the quantitative analysis of the anterior-chamber in images obtained with 2 anterior-segment optical coherence tomography (AS-OCT) devices.

 
Methods:
 

Prospective cross-sectional observational study with 101 consecutive subjects over 40 years old recruited from a Singapore hospital. Image acquisition using Visante-OCT (Carl Zeiss Meditec, Dublin/USA) and SL-OCT (SL-OCT, Heidelberg Engineering, Heidelberg/Germany) was performed under the same room lighting conditions by a single operator in the same order. A single masked examiner with glaucoma subspecialty training performed the quantitative analysis on horizontal scans (nasal/temporal angles) using custom-built software included in the SL-OCT device and Zhongshan Angle Analysis Program (ZAAP, Guangzhou, China) for Visante-OCT images. The following parameters were assessed: angle-opening distance (AOD), trabecular-iris space area (TISA), central anterior-chamber depth (ACD), scleral-spur to scleral-spur distance (SpurD) and pupil diameter.

 
Results:
 

The scleral-spur was not detectable in 25 (25%) eyes imaged by SL-OCT and in 23 (23%) eyes imaged by Visante-OCT. The mean of differences (bias) was 6µm for ACD, 106µm for SpurD, and ranged from 88~110µm for AOD, and from 30~51µm2 for TISA. AOD and TISA values measured on SL-OCT images were significantly higher than the ones measured by Visante-OCT (p<0.001). The pupil diameter was significantly higher in Visante-OCT images (p<0.001).

 
Conclusions:
 

Difficulty in detecting the scleral-spur precluded the quantitative analysis of the anterior-chamber in more than 20% of the images obtained with either AS-OCT devices. When compared to Visante-OCT, SL-OCT tended to measure higher values for AOD and TISA. The use of visible light to aid the proper location of the scanning beam in SL-OCT may help explain these discrepancies.Figure: Quantitative analysis of anterior-segment from the same patient - Visante-OCT image (top), SL-OCT image (bottom)  

 
Keywords: clinical (human) or epidemiologic studies: risk factor assessment • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • anterior chamber 
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