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M. S. Spitzer, T. Chirambo, P. Kayange, E. Yoeruek, P. Szurman, K. U. Bartz-Schmidt, H. N. Batumba; Ocular Surface Squamous Neoplasia as the First and Only Apparent Manifestation of Hiv Infection in an Urban Patient Population in Southeast Africa. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5127.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the prevalence of undiagnosed and asymptomatic HIV infection in patients with ocular surface squamous neoplasia (OSSN) in an urban patient population in sub-Saharan Africa.
A consecutive series of patients presenting with OSSN was evaluated in an African academic center. A detailed history and physical examination in 53 consecutive patients with conjunctival squamous cell carcinoma (SCC) and conjunctival intra-epithelial neoplasia (CIN) was performed. 38 (72%) patients agreed to undergo serological HIV testing
79% (30 of 38) of all tested patients were HIV positive. None of the patients had previous HIV testing or was aware of having symptoms of HIV. 70% (n=21) of the HIV positive patients had no other symptoms suggestive of HIV infection or any other disease althoughmany patients recalled that the ocular tumor has been present for more than 6 to 12 months. Patients were far more likely to refuse HIV testing if they were married.
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