May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Microperimetric Evaluation of HIV-Related Retinal Microangiopathy
Author Affiliations & Notes
  • C. Fabiani
    Ocular Immunovirology Service, Department of Ophthalmology, University of Rome "La Sapienza", Italy
  • A. Bruscolini
    Ocular Immunovirology Service, Department of Ophthalmology, University of Rome "La Sapienza", Italy
  • L. De Carlo
    Ocular Immunovirology Service, Department of Ophthalmology, University of Rome "La Sapienza", Italy
  • M. P. Pirraglia
    Ocular Immunovirology Service, Department of Ophthalmology, University of Rome "La Sapienza", Italy
  • P. Pivetti Pezzi
    Ocular Immunovirology Service, Department of Ophthalmology, University of Rome "La Sapienza", Italy
  • Footnotes
    Commercial Relationships  C. Fabiani, None; A. Bruscolini, None; L. De Carlo, None; M.P. Pirraglia, None; P. Pivetti Pezzi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5130. doi:https://doi.org/
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      C. Fabiani, A. Bruscolini, L. De Carlo, M. P. Pirraglia, P. Pivetti Pezzi; Microperimetric Evaluation of HIV-Related Retinal Microangiopathy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5130. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To study HIV-related retinal microangiopathy by microperimetry.

Methods: : We conducted an observational case report on 26 eyes of 13 naïve HIV+ subjects. Patients underwent complete ocular examination together with fluorescein angiography and Ocular Coherence Tomography when needed. Microperimetry NIDEK MP-1 (10-2, threshold 4-2) was used to quantify retinal sensitivity. Patients were evaluated at baseline (naïve patients) and after 6 months of HAART therapy.

Results: : At baseline 16 eyes showed normal fundoscopic examination, while 10 eyes disclosed retinal cotton wool spots (CWS), typical manifestation of microangiopathy. In all eyes microperimetry documented a decrease in focal sensitivity of CWS affected retina and of the superotemporal perivascular area (mean sensitivity values: 17.3 dB). After 6 months of HAART therapy we observed the resolution of CWS in all patients and an improvement in retinal sensitivity if compared to baseline values (mean sensitivity values: 18.9 dB). A similar improvement in retinal sensitivity was measured in the superotemporal perivascular area of the 16 eyes without typical microangiopathy’s signs.

Conclusions: : Our study suggests that microperimetry in HIV+ patients might be a useful tool in order to investigate the presence and the evolution of retinal HIV-related microangiopathy. Retinal sensitivity should be included as an additional outcome measure in HIV+ patients as it might reveal subclinical microangiopathy. HAART therapy seems to improve retinal sensitivity without toxic effects on retinal structures.

Keywords: AIDS/HIV • antiviral drugs • imaging/image analysis: clinical 
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