May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
A Scale for Confocal Tear Film Images Correlating With Clinical Tests for Dry Eye
Author Affiliations & Notes
  • R. W. Yee
    Department of Ophthalmology and Visual Science, Cizik Eye Clinic, Houston, Texas
  • J. Spindle
    Department of Ophthalmology and Visual Science, Cizik Eye Clinic, Houston, Texas
  • H. Sperling
    Department of Ophthalmology and Visual Science, Cizik Eye Clinic, Houston, Texas
  • A. Z. Chuang
    Department of Ophthalmology and Visual Science, Cizik Eye Clinic, Houston, Texas
  • Footnotes
    Commercial Relationships  R.W. Yee, SeeFit, P; J. Spindle, None; H. Sperling, None; A.Z. Chuang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5312. doi:https://doi.org/
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      R. W. Yee, J. Spindle, H. Sperling, A. Z. Chuang; A Scale for Confocal Tear Film Images Correlating With Clinical Tests for Dry Eye. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5312. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine if a noninvasive digital scanning slit confocal microscope with a 20x lens (Nidek Confoscan 4), can quantatively imaged and correlate with the tear film of patients with dry eye complaints using a newly developed standardize scale.

Methods: : A noninvasive digital scanning slit confocal microscope with a 20x lens (Nidek Confoscan 4) imaged the tear film of patients with dry eye complaints. Additionally, standard clinical tests for dry eye: lissamine green staining, meibomian gland secretion quantity and quality, and the basal tear test were measured. A ten-point scale for grading the tear film images captured by the ConfoScan 4 was developed based on the quantitative results from the standard clinical tests.

Results: : Fifty eight eyes of 29 patients, (21 females and 8 males), ranged in age from 13-84 years. A 1-10 scale was developed 1=normal and 10= abnormal based on the relative smoothness and uniformity of the images. 1. Increasing ocular surface damage as measured by the lissamine green staining total moderately correlates (R=0.314) with more abnormal tear film images as represented by a higher confocal image score. 2. Increasing quantity of tears produced in a five minute period as measured by the basal tear test shows a moderate correlation (R=0.356) to decreasing abnormalities of the tear film as represented by a lower confocal image score. 3. Worsening quality of the meibum as measured on our 3-point quality scale is strongly correlated (R=0.539) with increasing abnormalities of the tear film as represented by a higher confocal image score.

Conclusions: : Correlation of the clinical dry eye tests and confocal images suggest that the non contact comfocal imaging techniques may be a valuable tool for the study of the ocular surface disease.

Keywords: cornea: tears/tear film/dry eye • cornea: clinical science • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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