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L. M. Machado, R. S. Castro, B. M. Fontes; Staining Patterns in Dysfunctional Tear Syndrome: Rose Bengal versus Lissamine Green. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5320.
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To evaluate and compare corneal staining patterns of Lissamine Green (LG) versus Rose Bengal (RB) in patients with dysfunctional tear syndrome. Patient comfort after instillation of both drops was also addressed as a secondary goal.
Prospective, observational, comparative case-series. Patients were randomly chosen to participate on the study, and were divided in two groups regarding dye instillation order (Group A: RB first ; Group B: LG first). Both dyes were applied in regular intervals, and a staining score (van Bijsterveld scale) was used to correlate and compare the results. Disease severity was determined by the ocular surface disease index (OSDI). Comfort was evaluated by patient’s answer in an objective questionnaire.
Sixty eyes of thirty consecutive patients (24 females and six males) were studied. LG and RB showed good clinical correlation in both groups (Group A: r=0.939 ; Group B: r=0.915). LG was better tolerated than RB (p=0.003 in both groups). There was no statistical difference between groups regarding disease severity, gender or age.
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