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D. L. Burnes, D. M. de Bruin, J. Loewenstein, Y. Chen, S. Chang, T. Chen, D. D. Esmaili, J. F. de Boer; In vivo 3D Imaging of Age Related Macular Degeneration Using Optical Coherence Tomography at 1050 Nm. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5392.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the application of ophthalmic optical frequency domainimaging (OFDI) at 1050 nm, in combination with post-image processingmethods, for the detection of type I choroidal neovascularization(CNV) in patients with age related macular degeneration.
An OFDI system consisting of a swept laser with a bandwidthof 64nm centered at 1050nm was developed. Patients were imagedbefore treatment with ranibizumab, and subsequently imaged following4-8 treatments. The 3D image sets were processed with an anisotropicdiffusion filter to reduce noise and enhance edge contrast.The subretinal fluid, intra-retinal edema and CNV volumes weresegmented using connected threshold and level-set semi-automatedalgorithms. Enface images from the OFDI cross sections wereco-registered with color fundus photography (CFP) and fluoresceinangiography (FA), in addition to compiling CNV thickness maps.
In post treatment scans, the subretinal fluid and retinal edemavolumes were dramatically reduced if not completely absent,as well as a reduction in the CNV volume (see table). The CNVthickness maps correlate to the areas corresponding to confirmedand suspected CNV on FA.
The detailed images of the retina and choroid allow for obtainingvolumetric measurements of abnormal structures characterizingAMD using post-image processing methods. This technology maycontribute to early non-invasive diagnosis of AMD, and potentiallyserve as a valuable post-treatment monitoring tool.
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