May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
In vivo 3D Imaging of Age Related Macular Degeneration Using Optical Coherence Tomography at 1050 Nm
Author Affiliations & Notes
  • D. L. Burnes
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • D. M. de Bruin
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • J. Loewenstein
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • Y. Chen
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • S. Chang
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • T. Chen
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • D. D. Esmaili
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • J. F. de Boer
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  D.L. Burnes, None; D.M. de Bruin, None; J. Loewenstein, None; Y. Chen, None; S. Chang, None; T. Chen, None; D.D. Esmaili, None; J.F. de Boer, None.
  • Footnotes
    Support  NIH Grant EY014975
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5392. doi:https://doi.org/
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    • Get Citation

      D. L. Burnes, D. M. de Bruin, J. Loewenstein, Y. Chen, S. Chang, T. Chen, D. D. Esmaili, J. F. de Boer; In vivo 3D Imaging of Age Related Macular Degeneration Using Optical Coherence Tomography at 1050 Nm. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5392. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To assess the application of ophthalmic optical frequency domainimaging (OFDI) at 1050 nm, in combination with post-image processingmethods, for the detection of type I choroidal neovascularization(CNV) in patients with age related macular degeneration.

 
Methods:
 

An OFDI system consisting of a swept laser with a bandwidthof 64nm centered at 1050nm was developed. Patients were imagedbefore treatment with ranibizumab, and subsequently imaged following4-8 treatments. The 3D image sets were processed with an anisotropicdiffusion filter to reduce noise and enhance edge contrast.The subretinal fluid, intra-retinal edema and CNV volumes weresegmented using connected threshold and level-set semi-automatedalgorithms. Enface images from the OFDI cross sections wereco-registered with color fundus photography (CFP) and fluoresceinangiography (FA), in addition to compiling CNV thickness maps.

 
Results:
 

In post treatment scans, the subretinal fluid and retinal edemavolumes were dramatically reduced if not completely absent,as well as a reduction in the CNV volume (see table). The CNVthickness maps correlate to the areas corresponding to confirmedand suspected CNV on FA.

 
Conclusions:
 

The detailed images of the retina and choroid allow for obtainingvolumetric measurements of abnormal structures characterizingAMD using post-image processing methods. This technology maycontribute to early non-invasive diagnosis of AMD, and potentiallyserve as a valuable post-treatment monitoring tool.  

 

 
Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • image processing 
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