May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Is There Shared Genetic Determinant of Narrow Angle and Myopia? The Guangzhou Twin Eye Study
Author Affiliations & Notes
  • M. He
    Zhongshan Ophthalmic Center, Guangzhou, China
    UCL Institute of Ophthalmology, London, United Kingdom
  • Y.-M. Hur
    Chonnam National University, Gwangju, Republic of Korea
  • J. Zhang
    Zhongshan Ophthalmic Center, Guangzhou, China
  • D. Wang
    Zhongshan Ophthalmic Center, Guangzhou, China
  • B. Li
    Zhongshan Ophthalmic Center, Guangzhou, China
  • J. Ge
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Footnotes
    Commercial Relationships  M. He, None; Y. Hur, None; J. Zhang, None; D. Wang, None; B. Li, None; J. Ge, None.
  • Footnotes
    Support  National Natural Science Foundation of China (30772393), the China-Australia NSFC-DEST Special Fund (30371513), the Program for New Century Excellent Talents in University(NCET-06-0720)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5427. doi:https://doi.org/
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      M. He, Y.-M. Hur, J. Zhang, D. Wang, B. Li, J. Ge; Is There Shared Genetic Determinant of Narrow Angle and Myopia? The Guangzhou Twin Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5427. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Angle-closure and myopia have been traditionally considered as two separate phenotypes with different mechanism and determinants although the anatomical features of these two diseases are closely associated with each other. The purposes of the present study are to determine whether common sets of genes are operating in the angle closure traits and myopia-related traits and to estimate the extent to which common genetic and/of environmental factors influence the relationships

Methods: : The study participants were recruited from the Guangzhou Twin Registry and examined during the 2nd year phenotypic collection. ASOCT and custom software was used to quantify the anterior chamber parameters. Angle opening distance (AOD) at the location 500 µm anterior to scleral spur was selected as the measure of degree of angle width. Anterior chamber depth (ACD) and axial length (AL) were measured using a Zeiss IOLMaster. We computed twin correlations and cross-trait cross-twin correlations for monozygotic (MZ) and dizygotic (DZ) twins and carried out model-fitting analyses using a multivariate Cholesky model. All correlations were corrected for age and sex. The right eye was arbitrarily selected to represent the phenotypic characteristics of the specific individual.

Results: : 918 twins aged 8-16 years were available for analysis, which included 304 MZ and 155 DZ pairs. The phenotypic correlations among AL, ACD, and AOD were high as well as significant, ranging from 0.39 to 0.52. MZ twin correlations were significantly greater than DZ twin correlations for all three phenotypes, suggesting substantial genetic influences. MZ cross-twin cross-trait correlations were all greater than the corresponding DZ correlations, indicating that shared genetic factors play an important role in the covariations among the three phenotypes. When we standardized the Cholesky additive genetic factor loadings, of 80% of heritability for AOD, 17% were shared with the genetic factors that influence AL, 28% were in common with the genetic factors that affect ACD, and the remaining 35% were those genetic factors unique to AOD. Likewise, of 90% of heritability estimate for ACD, 31% were shared with the genetic factors that influence AL and 59% were those genetic factors unique to ACD.

Conclusions: : Genetic covariance for angle closure and myopic related quantitative traits was substantial, suggesting that shared genes may determine the relationships.

Keywords: anterior chamber • myopia • genetics 
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