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Y. Kiuchi, M. Takamatsu, T. Yokoyama, T. Kitaoka, T. Kumagami, M. Uematsu, E. Tsuiki, K. Neriishi, S. Fujiwara; Glaucoma Study in Atomic Bomb Survivors. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5444. doi: https://doi.org/.
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Although it is well known that radiation exposure induces cataracts, the effect of low-dose radiation on the prevalence of glaucoma is unknown. Several reports have examined the relationship between radiation and the prevalence of glaucoma; however, they are too incomplete to draw any conclusions. This study is designed to investigate the relationship between radiation dose and the prevalence of glaucoma in atomic bomb survivors. So far, we have examined a quarter of all subjects, and have collated the data to identify tendencies among subjects.
All atomic bomb survivors (3035 dose-available subjects) will be screened with an FDT Visual Field Screener, tonometry by a non-contact tonometer and a non-mydriatic fundus camera. Subjects who showed abnormal findings on the above examinations were referred to the University Hospitals in Hiroshima and Nagasaki. For the second examinations, subjects received stereo fundus photo, slit lamp examination, gonioscopy, applanation tonometry, and the Humphrey visual field test (SITA standard 30-2). The diagnostic methods followed the Tajimi glaucoma study (1) in Japan. All subjects were over 62 years old.
Seven hundred and twenty-two subjects had a screening test between October 2006 and April 2007. One hundred and forty-seven subjects (20.4 %) were diagnosed with glaucoma. The prevalence of primary open angle glaucoma was 4.3%, normal tension glaucoma was 12.9%, ocular hypertension was 1.7%, and primary angle closure glaucoma was 1.0%.
The prevalence (%) of all glaucoma was 20.4% in our subjects. The prevalence of angle closure glaucoma was the same as in the Tajimi study; however, the prevalence of normal tension glaucoma in our study was higher than in the Tajimi glaucoma study. The radiation dose may have an effect on this result.(1) Iwase et al. Ophthalmology 111: 1641-8, 2004
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