Purchase this article with an account.
A. L. Coleman, M. R. Wilson, A. Harris, E. Anastasopoulos, F. Yu, A. Koskosas, T. Pappas, P. Founti, F. Topouzis; Risk Factors for Open-Angle Glaucoma in the Thessaloniki Eye Study (TES). Invest. Ophthalmol. Vis. Sci. 2008;49(13):5450.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To report risk factors associated with open-angle glaucoma (OAG) in TES.
TES is a cross-sectional population-based study of glaucoma and other eye diseases in the Greek population of Thessaloniki. A total of 2554 subjects, randomly identified, were interviewed with a questionnaire and underwent a complete ophthalmologic examination. Participants were classified as open-angle glaucoma (OAG) according to specific criteria. Subjects with OAG were compared to controls with regards to demographic (age, sex), behavioral (smoking, alcohol, diet, sleep, BMI), systemic (hypertension, diabetes, diabetic treatment, history of cardiovascular diseases, migraines), and ophthalmic (IOP, pseudoexfoliation, and myopia) factors. Multivariate analysis, using multiple logistic regression models, were performed and included factors with p<0.2 in univariate analyses.
In TES, 135 OAG and 1668 controls were identified and included in the analysis. After adjustment for potential covariates, increased age (OR:1.07; 95% CI:1.04-1.10 per year) and increased IOP (OR:1.22; 95% CI:1.17-1.27 per mmHg) were associated with higher odds for OAG, while history of coronary artery bypass or vascular surgery showed borderline significance (OR:1.69; 95% CI:0.96-2.97). In the analysis restricted to those who were bilaterally phakic (104 OAG/ 1460 controls), pseudoexfoliation (OR:2.62; 95% CI:1.50-4.57) and mild (1-3 D) or moderate (>=3 D) myopia (OR:2.08; 95% CI:1.01-4.29 and OR:2.65; 95% CI:1.23-5.75, respectively), and history of coronary artery bypass or vascular surgery (OR:2.27; 95% CI:1.17-4.40) were associated with OAG, in addition to age and IOP.
Subjects who were older and had higher IOPs were more likely to have OAG in TES. In subjects who were bilaterally phakic, pseudoexfoliation, myopia, and a history of vascular surgery were also risk factors for OAG.
This PDF is available to Subscribers Only