May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Risk Factors for Open-Angle Glaucoma in the Thessaloniki Eye Study (TES)
Author Affiliations & Notes
  • A. L. Coleman
    Ophthalmology, Jules Stein Eye Inst, Los Angeles, California
  • M. R. Wilson
    Shool of Medicine, University of Colorado Denver and Health Sciences Center, Denver, Colorado
  • A. Harris
    Department of Ophthalmology, Indiana University, Indianapolis, Indiana
  • E. Anastasopoulos
    II Departement of Ophthalmology, Aristotle Univ Thessaloniki, Thessaloniki, Greece
  • F. Yu
    Ophthalmology, Jules Stein Eye Inst, Los Angeles, California
  • A. Koskosas
    II Departement of Ophthalmology, Aristotle Univ Thessaloniki, Thessaloniki, Greece
  • T. Pappas
    II Departement of Ophthalmology, Aristotle Univ Thessaloniki, Thessaloniki, Greece
  • P. Founti
    II Departement of Ophthalmology, Aristotle Univ Thessaloniki, Thessaloniki, Greece
  • F. Topouzis
    II Departement of Ophthalmology, Aristotle Univ Thessaloniki, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships  A.L. Coleman, None; M.R. Wilson, None; A. Harris, None; E. Anastasopoulos, None; F. Yu, None; A. Koskosas, None; T. Pappas, None; P. Founti, None; F. Topouzis, None.
  • Footnotes
    Support  International Glaucoma Association, UCLA Center for Eye Epidemiology, CA, Texas Tech University Health Sciences Center,TX, Pfizer, Inc.,NY, Glaucoma Research & Education Foundation, Indianapolis, IN
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5450. doi:https://doi.org/
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    • Get Citation

      A. L. Coleman, M. R. Wilson, A. Harris, E. Anastasopoulos, F. Yu, A. Koskosas, T. Pappas, P. Founti, F. Topouzis; Risk Factors for Open-Angle Glaucoma in the Thessaloniki Eye Study (TES). Invest. Ophthalmol. Vis. Sci. 2008;49(13):5450. doi: https://doi.org/.

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Abstract

Purpose: : To report risk factors associated with open-angle glaucoma (OAG) in TES.

Methods: : TES is a cross-sectional population-based study of glaucoma and other eye diseases in the Greek population of Thessaloniki. A total of 2554 subjects, randomly identified, were interviewed with a questionnaire and underwent a complete ophthalmologic examination. Participants were classified as open-angle glaucoma (OAG) according to specific criteria. Subjects with OAG were compared to controls with regards to demographic (age, sex), behavioral (smoking, alcohol, diet, sleep, BMI), systemic (hypertension, diabetes, diabetic treatment, history of cardiovascular diseases, migraines), and ophthalmic (IOP, pseudoexfoliation, and myopia) factors. Multivariate analysis, using multiple logistic regression models, were performed and included factors with p<0.2 in univariate analyses.

Results: : In TES, 135 OAG and 1668 controls were identified and included in the analysis. After adjustment for potential covariates, increased age (OR:1.07; 95% CI:1.04-1.10 per year) and increased IOP (OR:1.22; 95% CI:1.17-1.27 per mmHg) were associated with higher odds for OAG, while history of coronary artery bypass or vascular surgery showed borderline significance (OR:1.69; 95% CI:0.96-2.97). In the analysis restricted to those who were bilaterally phakic (104 OAG/ 1460 controls), pseudoexfoliation (OR:2.62; 95% CI:1.50-4.57) and mild (1-3 D) or moderate (>=3 D) myopia (OR:2.08; 95% CI:1.01-4.29 and OR:2.65; 95% CI:1.23-5.75, respectively), and history of coronary artery bypass or vascular surgery (OR:2.27; 95% CI:1.17-4.40) were associated with OAG, in addition to age and IOP.

Conclusions: : Subjects who were older and had higher IOPs were more likely to have OAG in TES. In subjects who were bilaterally phakic, pseudoexfoliation, myopia, and a history of vascular surgery were also risk factors for OAG.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment 
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