May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Prevalence and Risk Factors for Primary Open Angle Glaucoma in Andhra Pradesh Eye Disease Study
Author Affiliations & Notes
  • K. Sannapaneni
    ICARE, L V Prasad Eye Institute, Hyderabad, India
  • C. Garudadri
    ICARE, L V Prasad Eye Institute, Hyderabad, India
  • R. C. Kanna
    ICARE, L V Prasad Eye Institute, Hyderabad, India
  • S. Senthil
    ICARE, L V Prasad Eye Institute, Hyderabad, India
  • J. Keeffe
    ICARE, L V Prasad Eye Institute, Hyderabad, India
  • N. Gullapalli
    ICARE, L V Prasad Eye Institute, Hyderabad, India
  • Footnotes
    Commercial Relationships  K. Sannapaneni, None; C. Garudadri, None; R.C. Kanna, None; S. Senthil, None; J. Keeffe, None; N. Gullapalli, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5456. doi:
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      K. Sannapaneni, C. Garudadri, R. C. Kanna, S. Senthil, J. Keeffe, N. Gullapalli; Prevalence and Risk Factors for Primary Open Angle Glaucoma in Andhra Pradesh Eye Disease Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5456.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the prevalence and risk factors for POAG in Indian state of Andhra Pradesh

Methods: : A population-based study using a stratified, random, cluster, systematic sampling strategy, was conducted in the state of Andhra Pradesh in India during 1996 to 2000. Participants from 94 clusters in one urban and 3 rural areas representative of the population of Andhra Pradesh underwent a detailed interview and a comprehensive ocular evaluation that included logarithm of minimum angle of resolution visual acuity, refraction, split lamp biomicroscopy, applanation tonometry and gonioscopy. Gonioscopy was performed with NMR-K 2 mirror gonio lens under appropriate testing conditions to define occludability before manipulating gonioscopy to visualize the angle structures. In participants with occludable angles pupils were not dilated. All other participants underwent pupilary dilatation and detailed fundus evaluation. Humphrey full threshold 24-2 visual fields were performed when indicated by standardized criteria for disc cupping or if intraocular pressure was more than or equal to 22 mm of Hg. Trained professionals performed all examinations. POAG was diagnosed and categorized using International Society of Geographical and Epidemiological Ophthalmology classification

Results: : POAG was present in 82 of 3724 subjects, an age and gender adjusted prevalence of 2.2% (95% CI, 1.73 - 2.67). Diagnosis of POAG was based on category I in 72, category II in 6 and category III in 4 subjects. Subjects with POAG (59.9 ± 10.7 years) were older (P<0.001) than normal population (54.5 ± 10.3 years). Ninety five percent (78/82) of the patients with POAG were not aware of their disease. The prevalence of blindness due to POAG was 23.2% (19/82). There was increased risk of POAG with increasing age (P<0.001) and intraocular pressure (P<0.001). There was no significant association with gender, myopia, systemic hypertension, diabetes or socioeconomic status

Conclusions: : The prevalence of POAG in Andhra Pradesh in population 40 years or older was 2.2%.The risk increased with increase in intraocular pressure and age. Ninety five percent were not aware of having glaucoma and 23.2% were blind

Keywords: clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology 
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