May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Pseudoexfoliation in a Mongolian Population
Author Affiliations & Notes
  • W. P. Nolan
    Glaucoma department, Birmingham and Midland Eye Centre, Birmingham, United Kingdom
  • J. Yip
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • D. Uranchimeg
    Department of Ophthalmology, Health Sciences University, Ulaanbaatar, Mongolia
  • J. Baasanhu
    Department of Ophthalmology, Health Sciences University, Ulaanbaatar, Mongolia
  • P. S. Lee
    Department of Epidemiology,
    Institute of Ophthalmology, London, United Kingdom
  • P. T. Khaw
    Department of Pathology and Wound Healing,
    Institute of Ophthalmology, London, United Kingdom
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • G. J. Johnson
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • P. J. Foster
    Department of Epidemiology,
    Institute of Ophthalmology, London, United Kingdom
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • C. Gilbert
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • Footnotes
    Commercial Relationships  W.P. Nolan, None; J. Yip, None; D. Uranchimeg, None; J. Baasanhu, None; P.S. Lee, None; P.T. Khaw, None; G.J. Johnson, None; P.J. Foster, None; C. Gilbert, None.
  • Footnotes
    Support  Wellcome Trust, Christian Blind Mission, British Council for Prevention of Blindness, National Lotteries Board through Fight for Sight.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5457. doi:
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      W. P. Nolan, J. Yip, D. Uranchimeg, J. Baasanhu, P. S. Lee, P. T. Khaw, G. J. Johnson, P. J. Foster, C. Gilbert; Pseudoexfoliation in a Mongolian Population. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5457.

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Abstract
 
Purpose:
 

To describe the prevalence of pseudoexfoliation (PXF) in Mongolia.

 
Methods:
 

In the context of a randomized controlled trial of screening for angle closure 2029 adult volunteers aged >49 yrs (747 (36.8%) men) underwent a slit-lamp examination. IOP was measured using Goldman tonometry. Gonioscopy was performed according to the Spaeth scheme. Presence of PXF material on the lens was ascertained after pupil dilation. Patients with PXF were classified with secondary open angle glaucoma (sOAG), secondary angle closure glaucoma (sACG), primary angle closure (PAC), or primary angle closure suspects (PACS) (occludable angles) according to the ISGEO definitions. Anterior chamber depth (ACD) was measured using A-Scan biometry. The association between age, gender, ACD, and an occludable angle with PXF was assessed using chi squared test for categorical variables and t-test or the Wilcoxon rank sum test. Logistic regression was used in a multivariate analysis.

 
Results:
 

Pseudoexfoliation was present in 164 participants (8.1%) (69 male, 95 female, p =0.307) and was associated with increasing age (p<0.01). Of these, 21/164 (12.8%) were diagnosed with glaucoma (8 sACG, 12 sOAG, 1 angle undeterminable) (Table 1). ACD was shallower in those with PXF (2.31mm;95% CI= 2.20-2.42) compared to participants without PXF (2.47mm;2.45-2.50) (p < 0.01). Participants with PXF were more than twice as likely to have an occludable angle after age was accounted for (OR=2.20; 1.48-3.27)(p<0.01).

 
Conclusions:
 

A high prevalence of PXF was found in this Mongolian population. Cases with PXF had shallower anterior chambers and are more likely to have occludable drainage angles than the rest of this study population.  

 
Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • clinical (human) or epidemiologic studies: risk factor assessment 
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