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W. P. Nolan, J. Yip, D. Uranchimeg, J. Baasanhu, P. S. Lee, P. T. Khaw, G. J. Johnson, P. J. Foster, C. Gilbert; Pseudoexfoliation in a Mongolian Population. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5457.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the prevalence of pseudoexfoliation (PXF) in Mongolia.
In the context of a randomized controlled trial of screening for angle closure 2029 adult volunteers aged >49 yrs (747 (36.8%) men) underwent a slit-lamp examination. IOP was measured using Goldman tonometry. Gonioscopy was performed according to the Spaeth scheme. Presence of PXF material on the lens was ascertained after pupil dilation. Patients with PXF were classified with secondary open angle glaucoma (sOAG), secondary angle closure glaucoma (sACG), primary angle closure (PAC), or primary angle closure suspects (PACS) (occludable angles) according to the ISGEO definitions. Anterior chamber depth (ACD) was measured using A-Scan biometry. The association between age, gender, ACD, and an occludable angle with PXF was assessed using chi squared test for categorical variables and t-test or the Wilcoxon rank sum test. Logistic regression was used in a multivariate analysis.
Pseudoexfoliation was present in 164 participants (8.1%) (69 male, 95 female, p =0.307) and was associated with increasing age (p<0.01). Of these, 21/164 (12.8%) were diagnosed with glaucoma (8 sACG, 12 sOAG, 1 angle undeterminable) (Table 1). ACD was shallower in those with PXF (2.31mm;95% CI= 2.20-2.42) compared to participants without PXF (2.47mm;2.45-2.50) (p < 0.01). Participants with PXF were more than twice as likely to have an occludable angle after age was accounted for (OR=2.20; 1.48-3.27)(p<0.01).
A high prevalence of PXF was found in this Mongolian population. Cases with PXF had shallower anterior chambers and are more likely to have occludable drainage angles than the rest of this study population.
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