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J. B. Jonas, L. Xu, H. Zhang, Y. X. Wang; Central Corneal Thickness and Glaucoma in Adult Chinese: The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5461.
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To evaluate whether glaucoma is related to central corneal thickness (CCT).
The Beijing Eye Study 2006 is a population-based study including 3251 (73.3%) subjects (aged 45+ years) out of 4439 subjects who participated in the survey 2001 and who returned for re-examination. Main outcome measures were central corneal thickness and presence and progression of glaucomatous optic neuropathy.
Measurements of CCT were available for 3100 (95.4%) subjects. CCT did not vary significantly (P>0.10) between "Optic Disc Glaucoma" (n=77 (2.5%) subjects; 551±32µm), "Perimetric Glaucoma" (n=33 (1.1%) subjects; 548±32µm), and the normal group (556±33µm). CCT was not significantly associated with neuroretinal rim area (P=0.13) or mean visual field defect as measured by frequency doubling perimetry (P=0.71). In multiple regression analysis, CCT was significantly associated with male gender (P<0.001; Odds ratio (OR): 6.78; 95% confidence intervals (CI): 4.54, 9.06), urban region (P<0.001; OR: 3.86; 95%CI:1.52,6.20) and intraocular pressure measurements (P<0.001), while it was not significantly (P=0.42) associated with chronic open-angle glaucoma. In 124 (4.0%) ocular hypertensive subjects without glaucomatous optic disc abnormalities, mean CCT (582±34 µm) was significantly higher than in the normal group (P<0.001) and than in the glaucoma groups (P<0.001). During follow-up from 2001 to 2006, 42 subjects who showed a progression of, or development of glaucomatous abnormalities of the optic nerve head did not differ from the stable group in CCT.
CCT may not be markedly different between glaucomatous eyes and normal eyes. Reasons for discrepancies between the present population-based study and previous hospital-based investigations may be due to the study designs and selection of study participants.
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