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K. Ma, L. Xu, W. Cao, Y. Wang, C. Chen, X. Sun, J. B. Jonas; Anterior Chamber Depth and Chamber Angle and Their Associations With Ocular and General Parameters. The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5468.
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To investigate the normative data of anterior chamber depth and anterior chamber angle width and their associations with ocular and general parameters in adult Chinese.
The Beijing Eye Study 2006 included 3251 (73.3%) subjects (aged 45+ years) out of 4439 subjects who participated in the survey 2001 and who returned for re-examination. The subjects underwent a detailed ophthalmologic examination including measurement of the anterior chamber dimensions by slit-lamp based optical coherence tomography (OCT).
Out of the 3251 subjects, OCT measurements were available for 2985 (91.8%) subjects. Mean anterior chamber depth (ACD) measured 2.42 ± 0.34 mm and the mean anterior chamber angle (ACA) was 38.3 ± 16.3°. In multivariate analysis, a shallow chamber depth was significantly associated with age (P<0.001), hyperopic refractive error (P<0.001), female gender (P<0.001), short body stature (P=0.003), nuclear cataract (P=0.03), central corneal thickness (P<0.001), and presence of chronic angle-closure glaucoma (P<0.001). Correspondingly, a narrow anterior chamber angle was significantly associated with age (P<0.001), female gender (P<0.001), hyperopic refractive error (P<0.001), nuclear cataract (P<0.001), short body stature (P=0.001), and chronic angle-closure glaucoma (P<0.001). Chamber depth and angle width were not associated with presence of age-related maculopathy and diabetic retinopathy.
A shallow anterior chamber and a narrow anterior chamber angle in adult Chinese are associated with age, female gender, hyperopia, nuclear cataract, small optic disc, short body stature, and higher central corneal thickness. These findings may be helpful to find screening parameters to detect subjects at risk to develop angle-closure glaucoma.
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