May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Correlation of Visual Acuity Outcomes With OCT Measurements of the Outer Nuclear Layer and Intraretinal Cysts in Neovascular AMD Before and After Treatment With Ranibizumab
Author Affiliations & Notes
  • A. H. Kashani
    Ophthalmology, Doheny Eye Institute, University of Southern California, California
  • P. A. Keane
    Ophthalmology, Doheny Eye Institute, University of Southern California, California
  • S. R. Sadda
    Ophthalmology, Doheny Eye Institute, University of Southern California, California
  • Footnotes
    Commercial Relationships  A.H. Kashani, None; P.A. Keane, None; S.R. Sadda, Topcon, P.
  • Footnotes
    Support  IH grants EY03040, EY015914, R01 EY014375 and RetinoVit Stiftung, Cologne, Germany
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5577. doi:
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      A. H. Kashani, P. A. Keane, S. R. Sadda; Correlation of Visual Acuity Outcomes With OCT Measurements of the Outer Nuclear Layer and Intraretinal Cysts in Neovascular AMD Before and After Treatment With Ranibizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5577.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To quantify the outer nuclear layer (ONL)and intraretinal cystic spaces in patients with age-related macular degeneration (AMD) and determine if these parameters correlate with visual outcomes in patients that were treated with ranibizumab.

Methods: : Images were obtained using the Radial Line protocol of 6 high-resolution B-scans on a single StratusOCT machine. Graded spaces included intraretinal cystic spaces when present, the ONL, and the whole neurosensory retina. Thickness and volume of each space was calculated for 9 standard ETDRS subfields and foveal center point. Univariate and multivariate analysis (GEE, SAS) was used to correlate OCT parameters with visual acuity at baseline, 6, and 9 months post-ranibizumab injection.

Results: : Demographic characteristics of the population included 18% males with an average age of 78±6 years (mean±SD). Data here are reported for all 9 ETDRS subfields. Mean intraretinal cyst thickness and volume were 4.71±8.11µm and 0.35±1.13mm3, respectively. Mean ONL thickness and volume were 114.7±27.6µm and 3.24±0.78mm3 respectively. Mean ONL thickness and volume excluding cystic spaces were 110±24µm and 2.89±1.37mm3. Mean retinal thickness and volume were 265.4±33.2µm and 7.50±0.94mm3 respectively. In a univariate linear regression model using adjusted R2 values, ONL thickness was significantly correlated with logMAR visual acuity at baseline and 6 months (R2=0.11, p=0.04 at baseline and R2=0.12, p=0.05 at 6 months), though the correlations were small. ONL volume was also significantly correlated with logMAR visual acuity at baseline and 6 month time points (R2=0.11, p=0.04 at baseline and R2=0.12, p=0.05 at 6 months). Overall retinal thickness was also significantly correlated with visual acuity at baseline and 6 months (R2=0.19, p=0.02 at baseline and R2=0.14, p=0.05 at 6 months). None of the OCT parameters measuring overall retinal thickness, cystic spaces or ONL correlated significantly with 9 month visual acuity. In a multivariate linear regression analysis adjusting for ONL volume and retinal thickness no other variables were significantly correlated with visual acuity outcomes.

Conclusions: : This study suggests that ONL thickness and volume are positively correlated with visual outcomes in patients receiving intravitreal ranibizumab for neovascular AMD. However, this correlation likely only accounts for a small component of those visual outcomes.

Keywords: age-related macular degeneration • imaging/image analysis: clinical • choroid: neovascularization 
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