May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Ocular Decompression Pre-Intravitreal Injection Can Reduce the Magnitude of Postoperative Iop Spike
Author Affiliations & Notes
  • F. Quhill
    Macula Department, Wolverhampton and Midland Eye Infirmary, Solihull, United Kingdom
  • S. Pushpoth
    Macula Department, Wolverhampton and Midland Eye Infirmary, Solihull, United Kingdom
  • S. Mirza
    Macula Department, Wolverhampton and Midland Eye Infirmary, Solihull, United Kingdom
  • A. Hardwick
    Macula Department, Wolverhampton and Midland Eye Infirmary, Solihull, United Kingdom
  • Y. Yang
    Macula Department, Wolverhampton and Midland Eye Infirmary, Solihull, United Kingdom
  • Footnotes
    Commercial Relationships  F. Quhill, None; S. Pushpoth, None; S. Mirza, None; A. Hardwick, None; Y. Yang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5610. doi:https://doi.org/
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      F. Quhill, S. Pushpoth, S. Mirza, A. Hardwick, Y. Yang; Ocular Decompression Pre-Intravitreal Injection Can Reduce the Magnitude of Postoperative Iop Spike. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5610. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the effectiveness of Honan Balloon tamponade, pre-intravitreal injection, in reducing the magnitude of post-injection IOP spike.

Methods: : This was a randomised, single masked, two arm study. Thirteen eyes were recruited into the control arm, and ten eyes to the interventional arm. The interventional arm received a 5-minute ocular decompression with the Honan Balloon pre-injection, set at 30mmHg. The control arm received an intravitreal injection as normal with no pressure lowering manoeuvres.Patients were allocated to the two arms on an alternate basis as they presented to the Macular department at the Wolverhampton Eye Infirmary for intravitreal injection of Ranubizamab (Lucentis).IOP was measured in both groups pre-op and 60 minutes postop by a single masked observer. Injecting physicians were not involved in IOP measurement at any stage, and all eyes were injected with the standard volume of 0.05ml.Difference between two group means was tested for statistical significance using student t-test.

Results: : For the balloon group, change in IOP ranged from -7 to +7 mmHg (mean = +0.8). The control arm had post-injection IOP ranging from -1 to +20mmHg (mean = +6.8). The difference between mean post-IOP spikes was statistically significant (p < 0.005).

Conclusions: : Ocular decompression pre-intravitreal injection is an effective manoeuvre in reducing the magnitude of IOP spike post-injection. This additional step will further enhance the safety of this procedure of drug delivery.

Keywords: intraocular pressure • injection • vitreous 
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