May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Retinal Toxicity of Intravitreal Acyclovir: A Morphologic Study
Author Affiliations & Notes
  • F. M. Damico
    Retina Department, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • L. H. Young
    Retina Department, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  F.M. Damico, None; L.H. Young, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5625. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      F. M. Damico, L. H. Young; Retinal Toxicity of Intravitreal Acyclovir: A Morphologic Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5625. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To determine the morphologic effects of intravitreal acyclovir on the rabbit retina and the maximum non-toxic dose to the retina.

Methods: : Acyclovir (Acyclovir®, Bedford Laboratories, Bedford, OH) was injected in the vitreous of 51 Dutch Belted rabbits in five concentrations (0.1, 0.5, 1, 5, and 10 mg/0.1 ml). As control, the contralateral eye of each rabbit was injected with saline. Animals were periodically examined and photographed. They were sacrificed at different time points (1, 7, and 14 days, and 1 month) and inferior retina was analyzed by light and transmission electron microscopy.

Results: : Eyes injected with 10 mg of acyclovir showed complete destruction of external and internal photoreceptor segments, and disorganization of photoreceptors. Eyes injected with 5 mg of acyclovir showed outer segment disorganization. Eyes injected with 1 mg or less did not show any morphologic change on light microscopy, similar to eyes injected with saline. Two eyes, injected with 1 and 0.5 mg, were processed for electron microscopy and did not show any morphologic change.

Conclusions: : Intravitreal injections of 5 and 10 mg of acyclovir produce morphologic changes in rabbit retina, while injections of 1 mg or less seem to be safe. These data suggest that intravitreal injection of acyclovir is a potential treatment for the devasting herpetic retinitis. However more studies should be carried before it is used in clinical practice.

Keywords: antiviral drugs • retina 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×