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R. E. Coffee, III, J.-P. Hubschman, S. D. Schwartz; Experimental Model of Intravitreous Injection Techniques. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5635.
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To evaluate the amount of reflux from the needle tract after various intravitreous injection techniques in a porcine eye model.
To evaluate reflux through the needle tract after intravitreous injection the authors performed 150 injections of 0.05 ml and of 0.1 ml of methylene blue through the pars plana of 50 pig eyes. Comparisons of reflux were made using different needles (27, 30 and 32 gauge needles) and different techniques (depth and speed of injection). An endoscope was used to evaluate the flow of the drug and its location in the vitreous after the injection with the different techniques tested.
There was less reflux with the 32 and 30 gauge needles than with the 27 gauge needle. Less reflux was noted with deeper needle placement and with a 3 second delay prior to needle withdrawl from the globe.
Reflux after intravitreous injection is influenced by needle size and injection technique. Outcomes variation may be in part explained by loss of injected therapeutics at the time of injection. Optimizing drug delivery via intravitreous injection may be important in the management of our patients.
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