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G. Mishor, G. F. Schmid, T. Lifshitz, J. Levy, S. Rosen, J. M. Wild; Alterations in Higher-Order Aberrations Following Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5647.
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To determine the changes in higher-order aberrations (HOA) following cataract surgery.
The cohort comprised 39 eyes from 39 patients (mean age 73.1, SD 7.7) who had undergone cataract extraction by phacoemulsification and intra-ocular lens implantation. Eight HOAs (Total, TiltS1, High, TComa, TTrefoil, T4foil, TSph and HiAstg) were measured using the NIDEK Optical Path Difference Scanning System ARK-10000 aberrometer prior to surgery (Mean 3.5 weeks, SD 2.0), approximately 10 weeks post operatively (Mean 10.7 weeks, SD 7.6) (PO1) and approximately 18 months post-operatively (Mean 18.6 months, SD 3.5) (PO2). The root mean square (RMS) values for each HOA were separately compared over the three time periods.
Following cataract extraction and IOL implantation, the group mean RMS values for most HOAs progressively decreased in magnitude at PO1 and at PO2. However, the reductions in magnitude only reached statistical significance at PO1 for Total (p<0.001), Tilt (p=0.002), and High (p=0.039) and additionally at PO2 for T3foil (p=0.007), and TSph (p=0.004). The differences in magnitude between PO1 and PO2 did not reach statistical significance.
As would be expected, cataract extraction and IOL implantation resulted in an improvement in most aberrations at PO1 and this improvement was maintained at PO2. However, Tcoma and Hi-Astig remained unchanged and would therefore appear to be largely independent of the crystalline lens. This latter finding has implications for the design of future IOLs.
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