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A. Dhamija, Z. M. S. Corrêa, J. J. Augsburger, A. H. Shaikh; Relative Frequencies of Different Clinical Subtypes of Intraocular Lymphoma in an Ocular Oncology Practice. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5681. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the relative frequencies of different clinical subtypes of intraocular lymphoma in a single ocular oncology practice.
The clinical records of patients from the senior author’s practice (JJA) with probable diagnosis of intraocular lymphoma (IOL) evaluated between 1981 and 2007 were reviewed. Patients whose diagnosis was not confirmed pathologically or by associated clinical findings were excluded. Each patient’s intraocular lymphoma was assigned to one of the categories of intraocular lymphoma included in a practical clinical classification of intraocular lymphoma presented at the 2007 ARVO meeting.
Thirty-eight patients with intraocular lymphoma were identified. Twenty-two of these patients (57.9%) were women and 16 (42.1%) were men. The median age at diagnosis was 65.5 years. The ocular tissues involved most frequently were vitreous in 26 cases (68.4%), retina and/or subretinal space in 20 cases (52.6%), and uvea in 10 cases (26.3%). The assigned clinical category of intraocular lymphoma in the 38 cases was primary vitreoretinal lymphoma in 28 (73.7%), primary uveal lymphoma in 5 (13.2%), metastatic intraocular lymphoma in 4 (10.5%), and secondary intraocular lymphoma in 1 (2.6%).
The vitreoretinal form of primary intraocular lymphoma was encountered much more frequently in this series than all other clinical subtypes combined. However, primary uveal lymphoma and metastatic intraocular lymphoma were encountered in several patients each in this series and were clearly recognizable as distinct from the primary vitreoretinal form.
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