May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Etiology of Keratoprosthesis Loss: Results From the Boston Keratoprosthesis Multicenter Study
Author Affiliations & Notes
  • J. B. Ciolino
    Cornea, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Ophthalmology, Albany Medical College, Albany, New York
  • J. W. Ament
    Cornea, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • B. L. Zerbe
    Ophthalmology, Albany Medical College, Albany, New York
  • M. W. Belin
    Ophthalmology, Albany Medical College, Albany, New York
  • Footnotes
    Commercial Relationships  J.B. Ciolino, None; J.W. Ament, None; B.L. Zerbe, None; M.W. Belin, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5712. doi:https://doi.org/
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      J. B. Ciolino, J. W. Ament, B. L. Zerbe, M. W. Belin; Etiology of Keratoprosthesis Loss: Results From the Boston Keratoprosthesis Multicenter Study. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5712. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report causes of failure to retain the Boston Type 1 Keratoprothesis

Methods: : Pre-operative and post-operative data was collected and analyzed from the Boston Keratoprosthesis Multicenter Study Group (22 surgeons).

Results: : 21 of 252 implanted keratoprosthesis were not retained. Overall the retention rate was 91.6% (average follow-up of 13 months, range 1 - 53 months).25.6% (11/ 43) of patients with autoimmune disease failed to retain the KPro. 9 of the autoimmune KPro’s lost developed a cornea melt around the implant requiring its replacement.10.7% (3/ 28) KPro’s with a history of chemical injury required replacement. 2 due to thinning of the peripheral donor cornea at the donor-host interface.Only 3.8% (7/ 181) of the remaining KPro’s were not retained. 3 of the eyes were enucleated after large retinal detachments, 2 were replaced due to fungal keratitis, and 2 experienced a corneal melt around the implant.

Conclusions: : Patients with autoimmune disease have the poorest KPro retention mostly due to cornea melting around the implant. Patients with chemical injuries also have a guarded prognosis and appear to be at a higher risk of thinning of the peripheral donor cornea. Patients lacking chemical injury or autoimmune disease have an excellent retention rate (96%).

Keywords: keratoprostheses • cornea: stroma and keratocytes 
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