May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Long Term Outcome of ex vivo Cultivated Limbal Epithelial Transplantation(CLET) for Limbal Stem Cell Deficiency(LSCD)
Author Affiliations & Notes
  • V. S. Sangwan
    Cornea & Ocular Immunology, LV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
  • R. Swarup
    Cornea & Ocular Immunology, LV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
  • G. K. Vemuganti
    Sudhakar & Srikanth Ravi Stem Cell Biology Laboratory, Brien Holden Research Center, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Andhra Pradesh, India
  • A. Fatima
    Cornea & Ocular Immunology, LV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
  • G. N. Rao
    Cornea & Ocular Immunology, LV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
  • Footnotes
    Commercial Relationships  V.S. Sangwan, None; R. Swarup, None; G.K. Vemuganti, None; A. Fatima, None; G.N. Rao, None.
  • Footnotes
    Support  DBT, Govt Of India, HERF, Hyderabad
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5734. doi:https://doi.org/
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      V. S. Sangwan, R. Swarup, G. K. Vemuganti, A. Fatima, G. N. Rao; Long Term Outcome of ex vivo Cultivated Limbal Epithelial Transplantation(CLET) for Limbal Stem Cell Deficiency(LSCD). Invest. Ophthalmol. Vis. Sci. 2008;49(13):5734. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the long term clinical outcome of Cultivated limbal epithelial transplantation(CLET)

Methods: : Records of 19 patients who underwent CLET for Limbal stem cell deficiency(LSCD) following chemical injury between May and December 2001 were reviewed for demographics, etiology, transplant characteristics and outcome.

Results: : Follow-up ranged from 13 to 57 months(Mean: 42.8 months.)The mean reduction in conjunctivalisation was 2.36 quadrants. 10 patients(52.6% had a successful outcome with less than 1 quadrant of conjuctivalisation and 4(21%) had a partially successful outcome.

Keywords: cornea: clinical science • cornea: epithelium • regeneration 
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