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C. Shigeyasu, M. Kawashima, Y. Satake, K. Tsubota, J. Shimazaki; Comparison Between Autologous Limbal Transplantation and Cultivated Limbal Epithelial Transplantation to Chemical and Thermal Injury. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5740. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare outcomes of autologous limbal transplantation (LT) and cultivated autologous limbal epithelial transplantation (CLET) for the treatment of severe ocular surface disorders due to chemical and thermal injury.
Retrospective analysis was made in 10 eyes of CLET for total limbal deficiency due to chemical and thermal injury. The results were compared with eyes undergone LT in a case-controlled manner in terms of age and severity. Both groups included seven males and three females. Mean(±SD) age of LT group was 39.7±21.0 years and CLET group was 41.2±18.7 years. We excluded patients with followed-up period of less than 12 months. We compared CVA and the stability of the corneal surface between them.
Combined surgery with keratoplasty was performed in 2 eyes of CLET group. Secondary keratoplasty was performed in 5 eyes in the LT group and 4 eyes in the CLET group. Pre-operative average CVA was 20/2000 in both groups. Post-operative average CVA was 20/400 and 20/500 at 3 months, 20/250 and 20/600 at 6 months and 20/300 and 20/600 at 12 months after surgery in the LT and CLET groups, respectively. There was a statistically significant improvement of CVA after 12 months in both groups (LT: P=0.041, CLET: P=0.037), although there were no statistical differences between the groups. Although the stable ocular surface was achieved in 8 eyes of the LT group and 6 eyes of the CLET group, corneal superficial neovasculization were more common and transparency seemed to be less in the CLET group. During the follow-up, corneal ulcer was seen in one eye in each group and secondary glaucoma was noted in one eye and 2 eyes in the in LT and CLET groups, respectively. There were no complications in the donor eyes.
Both autologous LT and CLET are useful for the stability of the corneal surface in severe chemical and thermal injury.
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