May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Recording Focal Macular Photopic Negative Responses (PhNRs) in Monkey Retina
Author Affiliations & Notes
  • Y. Kurimoto
    Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • M. Kondo
    Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • T. Sakai
    Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • T. Koyasu
    Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • K. Miyata
    Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • H. Terasaki
    Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Footnotes
    Commercial Relationships  Y. Kurimoto, None; M. Kondo, None; T. Sakai, None; T. Koyasu, None; K. Miyata, None; H. Terasaki, None.
  • Footnotes
    Support  Health Sciences Research Grants (H19-sensory-001)
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 5815. doi:https://doi.org/
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    • Get Citation

      Y. Kurimoto, M. Kondo, T. Sakai, T. Koyasu, K. Miyata, H. Terasaki; Recording Focal Macular Photopic Negative Responses (PhNRs) in Monkey Retina. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5815. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To study the properties of the photopic negative response (PhNR) of focal macular electroretinograms (fmERGs) elicited by different stimulus intensities and stimulus durations in monkeys.

Methods: : The focal macular PhNRs were recorded from five rhesus monkeys using a modified infrared fundus camera, in which a red LED (=627 nm) stimulus spot and blue LED (=450 nm) background illumination were incorporated. The stimulus intensity and duration were changed and presented on a blue background of 3.7 log scot-td. The effect of stray-light on the focal ERGs was studied by recording focal ERGs from a retinal site damaged by focal laser coagulation.

Results: : After the photocoagulation, "focal" ERGs were obtained with red intensities <3.5 log phot-td (55 cd/m2) on a steady blue background of 3.7 log scot-td. The amplitude of focal macular PhNR increased with increasing stimulus intensities, and was 5.9±0.5 µV for a 15 degree stimulus spot of 10 msec duration at 55 cd/m2. The amplitude of focal macular PhNR was dependent on the stimulus duration, and was larger for longer stimulus durations of 30-150 msec.

Conclusions: : It is possible to record focal macular PhNRs from the primate retina with red stimulus spot on a blue background. Focal macular PhNRs can be used to study the inner retinal function of localized areas in normal and diseased retinas.

Keywords: electroretinography: non-clinical • electrophysiology: non-clinical • ganglion cells 
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