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Y. Kurimoto, M. Kondo, T. Sakai, T. Koyasu, K. Miyata, H. Terasaki; Recording Focal Macular Photopic Negative Responses (PhNRs) in Monkey Retina. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5815. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To study the properties of the photopic negative response (PhNR) of focal macular electroretinograms (fmERGs) elicited by different stimulus intensities and stimulus durations in monkeys.
The focal macular PhNRs were recorded from five rhesus monkeys using a modified infrared fundus camera, in which a red LED (=627 nm) stimulus spot and blue LED (=450 nm) background illumination were incorporated. The stimulus intensity and duration were changed and presented on a blue background of 3.7 log scot-td. The effect of stray-light on the focal ERGs was studied by recording focal ERGs from a retinal site damaged by focal laser coagulation.
After the photocoagulation, "focal" ERGs were obtained with red intensities <3.5 log phot-td (55 cd/m2) on a steady blue background of 3.7 log scot-td. The amplitude of focal macular PhNR increased with increasing stimulus intensities, and was 5.9±0.5 µV for a 15 degree stimulus spot of 10 msec duration at 55 cd/m2. The amplitude of focal macular PhNR was dependent on the stimulus duration, and was larger for longer stimulus durations of 30-150 msec.
It is possible to record focal macular PhNRs from the primate retina with red stimulus spot on a blue background. Focal macular PhNRs can be used to study the inner retinal function of localized areas in normal and diseased retinas.
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