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M. A. Memon, J. Chen, S. J. Kim, L. Snebold, F. Masrur, D. B. Shire, M. Kenney, J. F. Rizzo; Surgical Methods for Implantation of Dual Sub-Retinal Electrode Arrays Into One Minipig Eye. Invest. Ophthalmol. Vis. Sci. 2008;49(13):5877. doi: https://doi.org/.
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This work is related to the efforts of the Boston Retinal Implant Project to develop a sub-retinal prosthesis to restore vision to the blind. The specific purpose of this presentation is to develop a safe surgical method to implant two sub-retinal electrode arrays in the same eye, which could conceivably be used to provide central and peripheral vision.
7 Yucatan miniature pig eyes were implanted with Inactive, HD Microsystems PI-2611 polyimide arrays using ab externo approach. Two array designs were used. The ‘small’ array was 1.510 mm x 101.5 mm x 15 µm, with 15 Iridium Oxide electrodes (400 microns in diameter). The ‘large’ array was 5 mm in diameter and 16 microns thick, with 100 Iridium Oxide electrodes (200 microns in diameter). In 2 survival surgeries and in one acute surgery, a single scleral flap was created temporally 8mm posterior to the limbus for insertion of both arrays. In 4 acute surgeries, nasal and temporal flaps were created 8 mm posterior to the limbus to insert each array separately. Arrays were inserted with the help of a guide.
Among the 5 acute surgeries, a large array and a small array were successfully implanted in one eye through a single scleral flap; two small arrays were successfully implanted in another eye through two, separate scleral flaps. Two small arrays were successfully implanted in the other 3 eyes via two slceral flaps, while large arrays were only partially sub-retinal. Among the 2 survival surgeries with a single scleral flap, a large and small array were successfully implanted, while the second surgery failed due to retinal incarceration secondary to choroidal rupture during cauterization.
A large array and a small array, or two small arrays could be implanted into the sub-retinal space of one minipig eye. Dual- array implantation has the potential to provide central vision through the small array and wider visual field through the large array. More experiments will be performed to develop this procedure.
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