May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Electroretinographic Findings in Pancreatic Enzyme Deficient and Pancreatic Enzyme Sufficient Cystic Fibrosis Populations
Author Affiliations & Notes
  • C. M. Suttle
    Optometry and Vision Science, University of New South Wales, Sydney, Australia
  • A. Whatham
    Optometry and Vision Science, University of New South Wales, Sydney, Australia
  • C. Blumenthal
    Department of Gastro-enterology, Children's Hospital at Westmead, Westmead, Australia
  • J. Allen
    Department of Gastro-enterology, Children's Hospital at Westmead, Westmead, Australia
  • K. Gaskin
    Department of Gastro-enterology, Children's Hospital at Westmead, Westmead, Australia
  • Footnotes
    Commercial Relationships  C.M. Suttle, None; A. Whatham, None; C. Blumenthal, None; J. Allen, None; K. Gaskin, None.
  • Footnotes
    Support  Cystic Fibrosis Research Trust
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 6100. doi:https://doi.org/
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    • Get Citation

      C. M. Suttle, A. Whatham, C. Blumenthal, J. Allen, K. Gaskin; Electroretinographic Findings in Pancreatic Enzyme Deficient and Pancreatic Enzyme Sufficient Cystic Fibrosis Populations. Invest. Ophthalmol. Vis. Sci. 2008;49(13):6100. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : We investigated scotopic and photopic electroretinographic (ERG) responses in children and young adolescents with cystic fibrosis who were either pancreatic insufficient (PI) or pancreatic sufficient (PS).

Methods: : ERG recordings were made from a mixed-gender group of 41 children and adolescents (4 to 18 years) with cystic fibrosis - 29 were pancreatic insufficient (PI) and 12 were pancreatic sufficient (PS). Full-field monocular ERGs were recorded from one eye, using a DTL fibre in the inferior cul-de-sac in conjunction with a Ganzfeld stimulus bowl (Radiometer Pacific, Sydney) and a portable stimulus trigger/averager (Medelec, Sydney). The pupil was dilated prior to recording, using two drops of 0.5% Tropicamide. Stimuli were scotopic weak flash, scotopic strong flash, photopic flash and photopic 30Hz flicker. Oscillatory potentials (OPs) were recorded to the scotopic strong flash. Serum levels of vitamin A, β Carotene and retinol binding protein (RBP) were also measured.

Results: : Implicit times of scotopic a and b waves and b wave amplitudes and implicit time and amplitude of photopic flash and 30Hz responses were not correlated with vitamin A, β Carotene or RBP levels. There was also no difference in these parameters between PI and PS groups. OP amplitudes were similar across the two groups.

Conclusions: : Current levels of enzyme supplementation are sufficient to prevent ERG abnormalities in the cystic fibrosis population.

Keywords: electroretinography: clinical • nutritional factors 
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