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C. M. Suttle, A. Whatham, C. Blumenthal, J. Allen, K. Gaskin; Electroretinographic Findings in Pancreatic Enzyme Deficient and Pancreatic Enzyme Sufficient Cystic Fibrosis Populations. Invest. Ophthalmol. Vis. Sci. 2008;49(13):6100.
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We investigated scotopic and photopic electroretinographic (ERG) responses in children and young adolescents with cystic fibrosis who were either pancreatic insufficient (PI) or pancreatic sufficient (PS).
ERG recordings were made from a mixed-gender group of 41 children and adolescents (4 to 18 years) with cystic fibrosis - 29 were pancreatic insufficient (PI) and 12 were pancreatic sufficient (PS). Full-field monocular ERGs were recorded from one eye, using a DTL fibre in the inferior cul-de-sac in conjunction with a Ganzfeld stimulus bowl (Radiometer Pacific, Sydney) and a portable stimulus trigger/averager (Medelec, Sydney). The pupil was dilated prior to recording, using two drops of 0.5% Tropicamide. Stimuli were scotopic weak flash, scotopic strong flash, photopic flash and photopic 30Hz flicker. Oscillatory potentials (OPs) were recorded to the scotopic strong flash. Serum levels of vitamin A, β Carotene and retinol binding protein (RBP) were also measured.
Implicit times of scotopic a and b waves and b wave amplitudes and implicit time and amplitude of photopic flash and 30Hz responses were not correlated with vitamin A, β Carotene or RBP levels. There was also no difference in these parameters between PI and PS groups. OP amplitudes were similar across the two groups.
Current levels of enzyme supplementation are sufficient to prevent ERG abnormalities in the cystic fibrosis population.
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