May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Foveal Dystrophy or Dysfunction: A Clinical Entity
Author Affiliations & Notes
  • N. W. Khan
    Ophthalmology, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, Michigan
  • J. R. Heckenlively
    Ophthalmology, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, Michigan
  • Footnotes
    Commercial Relationships  N.W. Khan, None; J.R. Heckenlively, None.
  • Footnotes
    Support  FFB
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 6103. doi:
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    • Get Citation

      N. W. Khan, J. R. Heckenlively; Foveal Dystrophy or Dysfunction: A Clinical Entity. Invest. Ophthalmol. Vis. Sci. 2008;49(13):6103. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To demonstrate that the multifocal electroretinogram (mfERG) is an effective tool for the detection of foveal dysfunction in the face of a normal standardized electroretinogram and other functional testing in patients complaining of subnormal vision and who have no foveal changes.

Methods: : Eight patients ages 16 to 62 years with complaints of reduced acuity were assessed with visual acuity, color vision testing (CV), Goldmann visual fields (GVF), mfERG (multifocal ERG), full-field ERG, fundus ophthalmoscopy, fundus photos, and optical coherence tomography (OCT). The mfERG was recorded as a scaled array of 103 hexagons and the amplitude and implicit time of six concentric rings were compared to those of normal control subjects (n=15). For each ring, the peak amplitude (difference between P1 and N1) and the implicit time of P1 were compared with controls.

Results: : In all subjects, acuity ranged from 20/30 to 20/400 in the worse eye. Color vision, tested with Ishihara Plates and the Farnsworth D-15 ranged from normal to severely affected color discrimination. GVFs were normal in six subjects and two subjects had central scotomas. Dark-adapted and light-adapted ERGs were normal in all subjects. Fundus examinations revealed no overt degeneration in the macular region. OCTs which were done on 6 patients, showed broadening and thinning of foveal pits. mfERGs showed significant amplitude reduction in the central rings 1 and 2 when compared to control.

Keywords: macula/fovea • degenerations/dystrophies • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 

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