May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Diagnostic Value of a Non-Invasive Protocol for Focal and Pattern ERG Recordings in Children With Macular and Optic Nerve Dysfunctions
Author Affiliations & Notes
  • F. Campagna
    Ophthalmology, Catholic University, Rome, Italy, Catanzaro, Italy
  • B. Falsini
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • G. Stifano
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • L. Montrone
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • M. Piccardi
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • D. Marangoni
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • A. Dickmann
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • W. Regini
    LACE Elettronica, Rome, Italy
  • E. Balestrazzi
    Ophthalmology, Catholic University, Rome, Italy, Rome, Italy
  • Footnotes
    Commercial Relationships  F. Campagna, None; B. Falsini, None; G. Stifano, None; L. Montrone, None; M. Piccardi, None; D. Marangoni, None; A. Dickmann, None; W. Regini, Employee, E; E. Balestrazzi, None.
  • Footnotes
    Support  Fondi di Ateneo, ex 60%
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 6104. doi:https://doi.org/
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      F. Campagna, B. Falsini, G. Stifano, L. Montrone, M. Piccardi, D. Marangoni, A. Dickmann, W. Regini, E. Balestrazzi; Diagnostic Value of a Non-Invasive Protocol for Focal and Pattern ERG Recordings in Children With Macular and Optic Nerve Dysfunctions. Invest. Ophthalmol. Vis. Sci. 2008;49(13):6104. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the diagnostic value of a non-invasive protocol for focal and pattern electroretinogram (FERG and PERG, respectively) recordings in children suffering from macular and optic nerve dysfunctions

Methods: : FERGs to 32 Hz flicker and PERGs to 8 Hz, 1.7 cycles/degree sinusoidal gratings, presented to the macular region (central 9 degrees), were recorded by skin electrodes in children (5 to 10 year old) with a clinically-established diagnosis of cone dystrophy (n = 15) or optic neuropathy (n = 15, inflammatory, compressive or traumatic). In both diagnostic groups visual acuity was comparable (Snellen equivalent: 0.4, range: 0.3-0.7). An age-similar control group of normal children (n = 15) was also tested.

Results: : In children with cone dystrophy, both FERGs and PERGs were reduced (p < 0.01) in amplitude and delayed in phase, compared to control values. In children with optic neuropathy, FERG amplitude was normal while PERG was reduced (p < 0.01) in amplitude compared to control values. In individual children, combined analysis of FERG and PERG responses correctly identified 100% of cone dystrophy (having both FERG and PERG abnormal) or optic neuropathy (having normal FERG and abnormal PERG) diagnoses.

Conclusions: : The current, non-invasive protocol for FERG and PERG recordings proved to be of diagnostic value, in a pediatric patient population, for discriminating primary macula from optic nerve dysfunctions

Keywords: electroretinography: clinical • macula/fovea • neuro-ophthalmology: diagnosis 
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