May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Retinal Hemorrhage After Intravitreal Avastin Injection- A Report of 2 Cases
L. Liu; C.-C. Lai; T.-L. Chen; K.-J. Yang; Y.-H. Kuo; A.-N. Chao; W.-C. Wu; K.-J. Chen; Y.-S. Hwang; Y.-P. Chen
Author Affiliations & Notes
  • L. Liu
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • C.-C. Lai
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • T.-L. Chen
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • K.-J. Yang
    Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan
  • Y.-H. Kuo
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • A.-N. Chao
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • W.-C. Wu
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • K.-J. Chen
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • Y.-S. Hwang
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • Y.-P. Chen
    Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • Footnotes
    Commercial Relationships L. Liu, None; C. Lai, None; T. Chen, None; K. Yang, None; Y. Kuo, None; A. Chao, None; W. Wu, None; K. Chen, None; Y. Hwang, None; Y. Chen, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 104. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Retinal Hemorrhage After Intravitreal Avastin Injection- A Report of 2 Cases
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      L. Liu, C.-C. Lai, T.-L. Chen, K.-J. Yang, Y.-H. Kuo, A.-N. Chao, W.-C. Wu, K.-J. Chen, Y.-S. Hwang, Y.-P. Chen; Retinal Hemorrhage After Intravitreal Avastin Injection- A Report of 2 Cases. Invest. Ophthalmol. Vis. Sci. 2007;48(13):104.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose:: To report 2 cases of retinal hemorrhage after intravitreal injection of avastin

Methods:: Case report

Results:: Case 1: A 52-year-old female came to our clinic due to acute onset of blurred vision and eye pain in both eyes. Ocular examination revealed elevated intraocular pressure(IOP) and iris neovascularization in both eyes. Fundoscopic examination showed mild non-proliferative diabetic retinopathy change. Under the impression of neovascular glaucoma, antiglaucoma medication was given and panretinal photocoagulation was performed in both eyes immediately. Intravitreal injection of 2.5mg/0.1ml of avastin was given in the right eye. 3 days later, the IOP elevated to 50mmHg in the right eye and diffused large blot retinal hemorrhage was observed. She received trabeculectomy on her right eye subsequently. Case 2: A 76 years old male had a history of coronary heart disease and diabetes mellitus came to our clinic due to progressive blurred vision of the left eye. He had vitreous hemorrhage presumably related to choroidal neovascularization and received pars plana vitrectomy in the right eye 1 year ago. His visual acuity was 0.1 in the right eye and 0.4 in the left. Optical coherence tomography revealed chroidal neovascularization and a small area of retinal pigment epithelial detachment (RPED). Fluorescence angiography revealed a parafoveal hyperfluorescence lesion. He received photodynamic therapy (PDT) on the left eye. However, subretinal hemorrhage occurred and the area of RPED enlarged involving fovea 6 weeks later. The hemorrhage persisted after 3 times of PDT. So intravitreal injection of 2.5mg/0.1ml avastin was done. However, 2 days after the injection, the subretinal hemorrhage increased.

Conclusions:: Intravitreal injection of avastin can cause retinal hemorrhage complicating its treatment course. The direct cause of hemorrhage deserves further investigation.

Keywords: retina • macula/fovea • diabetic retinopathy 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept