May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Effect of Cataract Extraction and Pseudophakia on the Measurement of Ganglion Cell Layer and Inner Plexiform Layer Thickness in Patients With and Without Primary Open Angle Glaucoma (POAG) Using OCT
Author Affiliations & Notes
  • D. Cabrera Fernandez
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • N. Sekhon
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • S. Ranganathan
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • H. M. Salinas
    Mount Sinai School of Medicine, New York, Florida
  • A. Bhorade
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • C. A. Puliafito
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • S. Yoo
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • D. Budenz
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida
  • Footnotes
    Commercial Relationships D. Cabrera Fernandez, None; N. Sekhon, None; S. Ranganathan, None; H.M. Salinas, None; A. Bhorade, None; C.A. Puliafito, Carl Zeiss Meditec, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, P; Carl Zeiss Meditec, R; S. Yoo, Alcon Labs, VISX, IntraLase, F; D. Budenz, Carl Zeiss Meditec, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, R.
  • Footnotes
    Support NIH R01 EY008684 HIGHWIRE EXLINK_ID="48:5:110:1" VALUE="EY008684" TYPEGUESS="GEN" /HIGHWIRE -10S1, P30-EY014801 HIGHWIRE EXLINK_ID="48:5:110:2" VALUE="EY014801" TYPEGUESS="GEN" /HIGHWIRE , Research to Prevent Blindness, Inc
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 110. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D. Cabrera Fernandez, N. Sekhon, S. Ranganathan, H. M. Salinas, A. Bhorade, C. A. Puliafito, S. Yoo, D. Budenz; The Effect of Cataract Extraction and Pseudophakia on the Measurement of Ganglion Cell Layer and Inner Plexiform Layer Thickness in Patients With and Without Primary Open Angle Glaucoma (POAG) Using OCT. Invest. Ophthalmol. Vis. Sci. 2007;48(13):110.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To investigate the effects of phacoemulsification and pseudophakia on the ganglion cell layer and inner plexiform (GCL+IPL) thickness measurements by Stratus OCT III.

Methods:: Thirteen patients who underwent phacoemulsification with lens implantation were analyzed. Eight patients were classified as glaucoma suspects. Fourteen normal eyes were used as controls. OCT was examined preoperatively and 4 weeks postoperatively. Macular thickness of the GCL+IPL, RNFL, INL, OPL and ONL was measured on horizontal and vertical OCT scans after automatic segmentation using a custom software program. Relative percentual difference in preoperative and postoperative measurements was calculated. The cataract’s effect on SNR was also evaluated. The results were analyzed using Wilcoxon matched pairs signed rank test (two-sided) and correlation analyses. For all analyses, p≤0.05 was considered to be statistically significant.

Results:: Increases in the GCL+IPL thickness after surgery were present in 92.30% of patients. A significant correlation was found between the GCL+IPL thickness before and after surgery (r=0.74, p=0.004 (vertical scans) and r=0.63, p=0.01 (horizontal scans)). No correlation was found for the remaining layers. The mean relative difference of GCL+IPL thickness before and after surgery in the population was 13.55% (vertical scans), and 14.12% (horizontal scans). The mean GCL+IPL thickness was 60.19 ± 9.10 microns before vs. 67.14 ± 12.30 microns after cataract surgery (p=0.013, vertical scans).The mean GCL+IPL thickness was 69.94 ± 11.44 microns before vs. 75.54 ± 11.27 microns after cataract surgery (p=0.026, horizontal scans ). The SNR showed a statistically significant increase after cataract removal (p=0.0002). Before cataract surgery, the GCL+IPL complex was thinner than in control eyes. This thinning effect was more noticeable for POAG suspects (12.23% vs. 2.26% thinning obtained for patients without retinal pathology).

Conclusions:: This study shows that significant changes occur in the thickness measurements of the GCL+IPL complex for POAG cases after cataract removal. SNR is enhanced after cataract surgery. Since a cloudy lens creates a distortion in the optical path difference of the light beam, OCT measurements might need some adjustments in order to properly quantify and diagnose glaucoma suspects in the presence of media opacities.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina • cataract 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×