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D. A. Rabenlehner, I. Krebs, S. Hagen, S. Binder; Changes of Area-Sizes in Fundus Autofluorescence After PDT for Choroidal Neovascularisation. Invest. Ophthalmol. Vis. Sci. 2007;48(13):147. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the changes of fundus autofluorescence (AF) after finalized photodynamic therapy (PDT) in eyes with choroidal neovascularisation (CNV) secondary to age related macular degeneration (AMD) and their impact on visual acuity.
Patients who had undergone standard PDT without recurrent activity of CNV were included in the study and examined in 3 months intervals up to 12 months after final PDT. AF images were obtained with Heidelberg Retina Angiograph using a 30-degree-field of view mode (excitation 488 nm, emission > 500nm). For image scaling and measurements ArchiCad-Software was used. Areas of hypo-AF were marked (borders of hypo- to normal or hyper-AF respectively) and calculated. Statistical evaluation was performed with the Spearman's rank correlation coefficient.
57 eyes of 57 patients (29 female, 28 male) with a mean age of 76.11 years (-/+ 8.19) were included. Area-size showing hypo-AF ranged from 0.86 mm2 to 28.79 mm2 (mean 9.65 +/-6.54 mm2) at baseline (1 month after final PDT). Hyper-AF zones around areas of Hypo-AF were found in 25 (43.9%) eyes. In 9 (15.8%) cases an enlargement of the hypo-AF area was observed. The mean progression at 12 months control compared to baseline-examination was 2.53 mm2 (+/- 1.88mm2) . 5 (55.5%) of these eyes did not show any zones of hyper-AF before enlargement. There was a correlation of area-size of hypo-AF and deterioration of visual acuity in statistical evaluation (p <0.003 between size of hypo-AF-area and visual acuity baseline, p <0.001 after one year).
After finalized PDT for CNV enlargement of hypo-AF areas can occur which may explain further deterioration of visual acuity. A direct correlation between enlargement of hypo-AF areas and surrounding hyper-AF zones could not be demonstrated, therefore one should be prudent to use this hyop-AF as a prognostic factor for progressive atrophy.
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