May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Characterization of Retinal Degeneration in SOD1-Deficient Mice: Electrophysiology and Histopathology
Y. Imamura; M. Hirasawa; K. Hashizume; S. Noda; T. Shirasawa; K. Shinoda; Y. Miyake; K. Tsubota
Author Affiliations & Notes
  • Y. Imamura
    Ophthalmology, Keio Univ School of Medicine, Shinjuku-Ku, Japan
  • M. Hirasawa
    Ophthalmology, Keio Univ School of Medicine, Shinjuku-Ku, Japan
  • K. Hashizume
    Ophthalmology, Keio Univ School of Medicine, Shinjuku-Ku, Japan
  • S. Noda
    Tokai Univ School of Nursing, Kanagawa, Japan
  • T. Shirasawa
    Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
  • K. Shinoda
    National Institute of Sensory Organ, Tokyo, Japan
  • Y. Miyake
    National Institute of Sensory Organ, Tokyo, Japan
  • K. Tsubota
    Ophthalmology, Keio Univ School of Medicine, Shinjuku-Ku, Japan
  • Footnotes
    Commercial Relationships Y. Imamura, None; M. Hirasawa, None; K. Hashizume, None; S. Noda, None; T. Shirasawa, None; K. Shinoda, None; Y. Miyake, None; K. Tsubota, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 21. doi:
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      Y. Imamura, M. Hirasawa, K. Hashizume, S. Noda, T. Shirasawa, K. Shinoda, Y. Miyake, K. Tsubota; Characterization of Retinal Degeneration in SOD1-Deficient Mice: Electrophysiology and Histopathology. Invest. Ophthalmol. Vis. Sci. 2007;48(13):21.

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Abstract

Purpose:: To examine the retinal function of mice lacking Cu,Zn-superoxide dismutase (SOD1) using electroretinogram and histology.

Methods:: Scotopic,photopic and flicker electroretinogram (ERG) were recorded from wild-type and Sod1-/- mice of different ages. The sensory retina was also examined histologically.

Results:: Aged Sod1-/- mice showed a decrease in the amplitude ofERGs. Retinal dysfunction appeared to progress with age. Histology revealed that retinal thinning and pigment cell migration co-existed with choroidal neovascularization (CNV) in aged Sod1-/- mice.

Conclusions:: Recently, we have reported that aged Sod1-/- mice showed drusen, thickened Bruch membrane, and CNV. Because retinal degeneration is a hallmark of dry type of age-related macular degeneration (AMD), our present results suggest Sod1-/-mouse be considered as a model of either wet or dry type of AMD. Moreover, these observations imply that these two conditions can be caused by deficiency of single gene.

Keywords: age-related macular degeneration • electrophysiology: non-clinical • retinal degenerations: cell biology 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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