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Y. Imamura, M. Hirasawa, K. Hashizume, S. Noda, T. Shirasawa, K. Shinoda, Y. Miyake, K. Tsubota; Characterization of Retinal Degeneration in SOD1-Deficient Mice: Electrophysiology and Histopathology. Invest. Ophthalmol. Vis. Sci. 2007;48(13):21. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the retinal function of mice lacking Cu,Zn-superoxide dismutase (SOD1) using electroretinogram and histology.
Scotopic,photopic and flicker electroretinogram (ERG) were recorded from wild-type and Sod1-/- mice of different ages. The sensory retina was also examined histologically.
Aged Sod1-/- mice showed a decrease in the amplitude ofERGs. Retinal dysfunction appeared to progress with age. Histology revealed that retinal thinning and pigment cell migration co-existed with choroidal neovascularization (CNV) in aged Sod1-/- mice.
Recently, we have reported that aged Sod1-/- mice showed drusen, thickened Bruch membrane, and CNV. Because retinal degeneration is a hallmark of dry type of age-related macular degeneration (AMD), our present results suggest Sod1-/-mouse be considered as a model of either wet or dry type of AMD. Moreover, these observations imply that these two conditions can be caused by deficiency of single gene.
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