May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
A Prospective Comparative Study of Functional and Structural Tests of Glaucomatous Damage
Author Affiliations & Notes
  • D. Xin
    Columbia University, New York, New York
    Department of Psychology,
  • V. C. Greenstein
    Columbia University, New York, New York
    Department of Ophthalmology,
  • T. M. Grippo
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • A. Llinas
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • J. S. Silverstein
    Columbia University, New York, New York
    Department of Psychology,
  • D. C. Hood
    Columbia University, New York, New York
    Department of Psychology,
  • J. M. Liebmann
    Department of Ophthalmology, Manhattan Eye Ear and Throat Hospital, New York, New York
  • R. Ritch
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • Footnotes
    Commercial Relationships D. Xin, Pfizer Inc., F; V.C. Greenstein, None; T.M. Grippo, None; A. Llinas, None; J.S. Silverstein, None; D.C. Hood, Pfizer Inc., F; J.M. Liebmann, None; R. Ritch, None.
  • Footnotes
    Support NIH Grant EY02115, Irving and Elaine Wolbrom Res Fd of NYGRI and Pfizer, Inc
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 217. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D. Xin, V. C. Greenstein, T. M. Grippo, A. Llinas, J. S. Silverstein, D. C. Hood, J. M. Liebmann, R. Ritch; A Prospective Comparative Study of Functional and Structural Tests of Glaucomatous Damage. Invest. Ophthalmol. Vis. Sci. 2007;48(13):217. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To compare frequency doubling perimetry (FDT), standard automated perimetry (SAP), multifocal visual evoked potentials (mfVEPs), pattern electroretinography (PERG) and optical coherence tomography (OCT) in glaucoma and evaluate the reproducibility of the measurements.

Methods:: Sixty-six eyes of 34 subjects with open-angle glaucoma and corrected visual acuity of >=20/40 were enrolled in a prospective study. To assess reproducibility and establish baseline measurements all patients were tested twice within a period of one month. At each visit FDT was performed with the Humphrey Matrix (24-2 program, ZEST), SAP with the Humphrey Field Analyzer II (24-2 program, SITA), mfVEPs with VERIS system using a 60 sector pattern-reversal dartboard array, PERGs with Glaid (LACE Elettronica) and optic disc and retinal nerve fiber layer assessments with OCT3. Reproducibility of each test was assessed by the following: mean deviation (MD) and pattern standard deviation (PSD) for FDT and SAP, response amplitudes and phase for PERGs, number of abnormal test locations with probability values of 1% and 5% for mfVEPs, and thickness of the superior and inferior quadrants and overall average thickness for the OCT.

Results:: The MD and PSD of the FDT and SAP were highly correlated (r>0.9) for the two visits, as were the number of abnormal test locations for the mfVEP, and thickness values for the OCT3 (r>0.9). The relationship was weaker for the PERG (phase r=0.8, amplitude r=0.6). A comparison between the global indices for the FDT and SAP showed a close linear relationship (MD r>0.9, PSD r>0.8). Qualitatively there was good agreement among the three functional visual field measures and structural tests regarding the presence of an abnormality (agreement>76%), and good agreement regarding the location of the deficit.

Conclusions:: The good reproducibility and agreement among these different functional and structural tests supports their use in a prospective study designed to detect glaucomatous progression.

Keywords: electrophysiology: clinical • imaging/image analysis: clinical • visual fields 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×