May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Intraocular Cytokines in the Treatment of Intraocular Lymphoma by Intravitreal Injection of Methotrexate
N. Yasuda; H. Kawamura; O. Sawada; M. Ohji
Author Affiliations & Notes
  • N. Yasuda
    Ophthalmology, Shiga University of Medical Science, Otsu, Japan
  • H. Kawamura
    Ophthalmology, Shiga University of Medical Science, Otsu, Japan
  • O. Sawada
    Ophthalmology, Shiga University of Medical Science, Otsu, Japan
  • M. Ohji
    Ophthalmology, Shiga University of Medical Science, Otsu, Japan
  • Footnotes
    Commercial Relationships N. Yasuda, None; H. Kawamura, None; O. Sawada, None; M. Ohji, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 253. doi:
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      N. Yasuda, H. Kawamura, O. Sawada, M. Ohji; Intraocular Cytokines in the Treatment of Intraocular Lymphoma by Intravitreal Injection of Methotrexate. Invest. Ophthalmol. Vis. Sci. 2007;48(13):253.

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Abstract

Purpose:: To evaluate the effectiveness of measuring anterior chamber interleukin-10 (IL-10) and IL-6 concentrations in the treatment of intraocular lymphoma by intravitreal injection of methotrexate.

Methods:: Two patients (3 eyes) underwent repeated weekly intravitreal injections of methotrexate for 6 weeks. We monitored the anterior chamber IL-10 and IL-6 concentrations and the IL-10/IL-6 ratio at baseline and at the last injections. IL-10 and IL-6 were determined using a standard enzyme-linked immunoassay.

Results:: Repeated intravitreal injections of methotrexate reduced vitreous opacity. The IL-10/IL-6 ratio consistently decreased in conjunction with clearance of vitreous opacity in 3 eyes; from 39.2 to 0.02, 1.67 to 0.03 and 3.05 to 0.159, respectively.

Conclusions:: A decrease in the IL-10/IL-6 ratio seems to be related to decreased vitreous opacity. Measuring the IL-10/IL-6 ratio in the anterior chamber may be useful to evaluate the effect of treatment of intraocular lymphoma.

Keywords: cytokines/chemokines • drug toxicity/drug effects • anterior chamber 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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