Abstract
Purpose::
To evaluate the rate of infectious and non-infectious endophthalmitis after intravitreal injection of bevacizumab.
Methods::
Clinical interventional case-series study. The study included 1218 intravitreal injections of 1.5 mg bevacizumab consecutively performed for 684 eyes with exudative age-related macular degeneration. Among the injections were 534 re-injections. Follow-up after each injection was at least 4 weeks.
Results::
One eye developed an infectious endophthalmitis 3 days after a second injection. In none of the other eyes, signs of an infectious or non-infectious endophthalmitis were observed such cellular infiltration or amorphous opacification of the vitreous, marked Tyndall phenomenon in the anterior chamber, retinal infiltration or pain.
Conclusions::
The rate of infectious endophthalmitis after an intravitreal injection of 1.5 mf bevacizumab may be about 1:1000, similar to injections of other drugs available so far.
Keywords: endophthalmitis • injection • age-related macular degeneration