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F. Mantelli, C. Moretti, A. Micera, A. Lambiase, S. Bonini, S. Bonini; Itchy-Dry Eye Associated With Polycystic Ovary Syndrome. Invest. Ophthalmol. Vis. Sci. 2007;48(13):414.
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The aim of this study is to define the ocular symptomatology of women with polycystic ovaries and hyperandrogenism.
Of the 62 consecutive patients with an ultrasonographic diagnosis of polycystic ovaries (PCO), 16 were identified as having clinical and biochemical signs of hyperandrogenism (PCOS). All women with a history of ocular symptoms (20/62 total patients=32.3%; 15/16 PCOS=93.7%; and 5/46 PCO=10.8% patients) received a complete eye examination with conjunctival impression cytology sampling. Clinical measurements of tear function (tear film break-up time, Schirmer I test) were completed along with analysis of conjunctival goblet cell number, conjunctival immunostaining and RT-PCR for the mucins MUC1 and MUC5AC. Clinical, histological and biochemical data of patients with PCOS were compared statistically to patients with PCO and to 8 age- and sex-matched healthy controls. Eight of the most severely affected patients received systemic anti-androgen therapy and underwent further ocular evaluation four months after systemic therapy.
Women with PCOS had greater conjunctival hyperemia (p<.001), dryness (p<.001), itching (p<.001), mucous discharge (p<.001) and contact lens intolerance (p<.001) than patients with PCO. Patients with PCOS had a significant reduction of the tear film break-up time accompanied by a significant increase in goblet cell number and conjunctival MUC5AC mRNA expression compared to both PCO and healthy subjects.
Females with PCOS were more likely to have itchy-dry eyes, decreased break-up time and increased goblet cell density. Our data show that evaluation of the ocular surface should be considered in patients with PCO/PCOS.
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