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S. Donati, S. Campanerut, F. DeMaria, P. Chelazzi, P. Sivelli, C. Azzolini; GDxVCC Polarimetry vs a New Optical Tomograph OCT/SLO on Retinal Nerve Fiber Thickness Evaluation in Early Glaucoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):497.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the abilities of GDxVCC polarimeter and the new tool OCT/SLO on the discrimination between healthy and early perimetric glaucomatous eyes based to retinal nerve fiber layer (RNFL) thickness analysis. To determine a significative conversion factor on the different measurement methods.
36 eyes of 36 patients (Group 1: 16 eyes of 16 healthy patients and Group 2: 20 eyes of 20 patients with early glaucoma with mean deviation - 3.7 +/- 3.0 dB and pattern standard deviation 4.5 +/- 2.7 dB) underwent imaging by the scanning laser polarimeter (GDxVCC; Zeiss) and OCT/SLO (OTI) RNFL scanning protocol. Results were analyzed with statistical T Student method. Correlation and regression tests were applied to evaluate and compare data.
Group 1 TSNIT Avg (Temporal-Superior-Nasal-Inferior-Temporal average) thickness was 61.15 µm with GDxVCC and 127.53 µm with OCT/SLO, in Group 2 48.6 µm with GDxVCC and 106.9 µm with OCT/SLO. The Superior average was respectively 78.27 µm with GDxVCC and 137.73 µm with OCT/SLO in Group 1, whereas Group 2 56.6 µm with GDxVCC and 128.6 µm with OCT/SLO. The Inferior average in Group 1 was 72.48 µm with GDxVCC and 145.93 µm with OCT/SLO, in Group 2 56.6 µm with GDxVCC and 112.4 µm with OCT/SLO. A statistically significant difference (p<0.05) on healthy and glaucomatous eyes RNFL thickness was obtained with two instruments; positive correlation on regression line were identified between GDxVCC and OCT/SLO data.
Our analysis showed the discriminative ability on early glaucoma detection of both GDxVCC and new OCT/SLO OTI instruments. TSNIT, Superior and Inferior RNFL Thickness variation on GDxVCC and OCT/SLO were significantly correlated. Trasversal-layer-scanning protocol on new OCT/SLO demonstrate comparable clinical efficacy as GDxVCC. A conversion factor has actually to be verified on a wider casuistry. Further studies will be applied on advanced glaucoma stage for the detection of RNFL damage.
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