Abstract
Purpose::
To determine the feasibility of scanning laser polarimetry (SLP) with variable corneal compensation (GDx-VCC), enhanced corneal compensation (GDx-ECC) and optical coherence tomography (OCT) for the retinal nerve fiber layer (RNFL) thickness evaluation in myopic glaucoma eyes.
Methods::
Seventy-three moderate myopic glaucoma eyes (spherical equivalent between -3 and -6diopter (D)) and 55 high myopic glaucoma eyes (spherical equivalent greater than -8D) were enrolled. RNFL measurement by GDx-VCC, GDx-ECC, OCT and also the visual field testing with a Humphrey Field Analyzer program 30-2 (HFA) were conducted in all subjects. The differences in RNFL thickness by GDx-VCC, GDx-ECC and OCT and also their association with visual field parameters were analyzed in both myopic groups.
Results::
There was no significant difference in HFA mean deviation (MD) between moderate and high myopic eyes (-7.56dB and -8.36dB, respectively. P=0.53). Both GDx-VCC and GDx-ECC derived RNFL thickness in high myopic group showed significantly higher values than those in moderate myopic group (p=0.001, p=0.002, respectively), while OCT-derived values were similar between the two groups (P=0.43). In both moderate and high myopic glaucoma groups, the association of RNFL values with MD HFA in GDx-VCC was poor compared with the association in GDx-ECC or OCT RNFL measurement. (Moderate myopia; GDx-VCC: r=0.198, GDx-ECC: r=0.502, OCT: r=0.573) (High myopia; GDx-VCC: r=0.359, GDx-ECC: r=0.457, OCT: r=0.626)
Conclusions::
GDx-ECC and OCT are useful for the RNFL evaluation in myopic glaucoma eyes, and become help to judge progress of glaucoma.
Clinical Trial::
Kyoto University
Keywords: nerve fiber layer • visual fields • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)