May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Fundus Image Obtained by Fourier Domain Optical Coherence Tomography for Glaucomatous Optic Disc
Author Affiliations & Notes
  • Y. Kotera
    Ophthalmology, Kyoto University, Kyoto, Japan
  • Y. Yasuno
    Institite of Applied Physics, Tsukuba University, Tsukuba, Japan
  • R. Inoue
    Ophthalmology, Kyoto University, Kyoto, Japan
  • S. Makita
    Institite of Applied Physics, Tsukuba University, Tsukuba, Japan
  • H. Nakanishi
    Ophthalmology, Kyoto University, Kyoto, Japan
  • M. Yamanari
    Institite of Applied Physics, Tsukuba University, Tsukuba, Japan
  • T. Yatagai
    Institite of Applied Physics, Tsukuba University, Tsukuba, Japan
  • N. Yoshimura
    Ophthalmology, Kyoto University, Kyoto, Japan
  • M. Hangai
    Ophthalmology, Kyoto University, Kyoto, Japan
  • Footnotes
    Commercial Relationships Y. Kotera, None; Y. Yasuno, None; R. Inoue, None; S. Makita, None; H. Nakanishi, None; M. Yamanari, None; T. Yatagai, None; N. Yoshimura, None; M. Hangai, None.
  • Footnotes
    Support a Grant-in-aid for Scientific Research (18591917) from JSPS
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 511. doi:
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      Y. Kotera, Y. Yasuno, R. Inoue, S. Makita, H. Nakanishi, M. Yamanari, T. Yatagai, N. Yoshimura, M. Hangai; Fundus Image Obtained by Fourier Domain Optical Coherence Tomography for Glaucomatous Optic Disc. Invest. Ophthalmol. Vis. Sci. 2007;48(13):511.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To assess the fundus images obtained by three-dimensional Fourier domain optical coherence tomography (FD-OCT) for a glaucomatous optic disc.

Methods:: Using FD-OCT, 22 eyes of 16 patients with open- angle glaucoma were examined. The OCT system used is a prototype standard-resolution spectral domain OCT system similar to TOPCON 3D-OCT-1000. The acquisition speed is 18,700 axial scans per second. A 3D OCT volume is acquired by a raster scanning using fast horizontal and slow vertical scans. The volume contains 256 (horizontal) × 256 (vertical) A-scans; the acquisition time for this is 3.5 s. In this study, we registered a photograph of the fundus and an OCT projection image by using manually selected control points.

Results:: The fundus image obtained using FD-OCT depicted various optic disc structures for which the OCT signal intensity was clearly different. The rim region expressed a low-reflection doughnut shape in the FD-OCT image. For all the eyes, the FD-OCT image showed clearly defined external rim margins. It showed clearly defined internal rim margins in 18 eyes (mean ± SD: 0.14 ± 2.12 diopters) and ill-defined margins in 4 (-1.31 ±2.77 diopters,). A peripapillary atrophy (PPA) in the fundus photograph was depicted as high intensity region by FD-OCT fundus image. Comparison with longitudinal cross-sectional images and color fundus photographs revealed that the external margin of the rim corresponded to the termination of PPA-ß or the retinal pigment epithelium in the area that had no PPA-ß. The internal rim margin was clearly defined when the direction in which the nerve fiber bundle approached the lamina cribrosa was nearly parallel to the probe light.

Conclusions:: With the exception of the internal rim margin in myopic eyes, the margins of optic disc structures are clearly displayed in fundus images obtained using FD-OCT based on the differences in the OCT signal intensities of these structures. The imaging method involving FD-OCT images of the fundus is potentially useful to assess the optic disc topography and provide optic disc parameters for the diagnosis of glaucoma.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc • nerve fiber layer 
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