May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Changes of Pattern Electroretinograms After Transcorneal Electrical Stimulation
Author Affiliations & Notes
  • K. Ogata
    Ophthalmology and Visual Science, Chiba University Guraduate School of Medicine, Chuo-Ku, Japan
  • S. Yamamoto
    Ophthalmology and Visual Science, Chiba University Guraduate School of Medicine, Chuo-Ku, Japan
  • Footnotes
    Commercial Relationships K. Ogata, None; S. Yamamoto, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 534. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K. Ogata, S. Yamamoto; Changes of Pattern Electroretinograms After Transcorneal Electrical Stimulation. Invest. Ophthalmol. Vis. Sci. 2007;48(13):534.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: It has been reported that electrical stimulation of the transected optic nerve stump enhanced the survival of retinal ganglion cells (RGCs) in rats. It was also reported that transcorneal electrical stimulation (TES) improved visual function in patients with optic neuropathy. The purpose of this study was to examine the changes of the pattern electroretinograms (ERGs) after TES to evaluate effects of TES on RGC function.

Methods:: TES was delivered through a bipolar contact lens electrode with biphasic electrical current (20Hz, 400µA) in 5 normal healthy subjects. Pattern ERGs were elicited by checkerboard stimuli and recorded before, immediately after, and at 1 week after TES.

Results:: Immediately after TES, the implicit time of P50 of the pattern ERG was significantly shortened (3-5 msec), and the amplitude of N95 was significantly increased to 170-180% of the pre-TES value in all subjects. These changes returned to the pre-TES value at 1 week after TES.

Conclusions:: These findings suggest that TES can alter RGC function transiently.

Keywords: electroretinography: clinical • clinical (human) or epidemiologic studies: systems/equipment/techniques • ganglion cells 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×