Complication After Intravitreal Bevacizumab (Avastin): Analysis of 1910 Injections

Abstract

Purpose:: To determine the ocular and systemic complications after intravitreal Bevacizumab (Avastin) injection

Methods:: Retrospective study. We reviewed records of patients that were injected with 2,5 mg/0,1 ml of intravitreal Bevacizumab (Avastin) in a period of fourteen months in the Retina Service of Asociacion para Evitar la Ceguera en Mexico.

Results:: Records of 1910 injections were reviewed. Four patients (0.2%) with proliferative diabetic retinopathy developed tractional retinal detachment(TRD). Three cases(0.15%) of endophtalmitis , one rhegmatogenuos retinal detachmen (RRD)(0.05%), and one vitreous hemorrhage(VH) (0.05%) were also observed. No systemic effect was reported.

Conclusions:: Out of 1910 injections our rate of ocular complications was 0,47%. (TRD, RRD, VH and endophthalmitis). No systemic complications were observed.

Keywords: injection • clinical (human) or epidemiologic studies: prevalence/incidence • retina