May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Age Related Differences in Lid Margin Health
Author Affiliations & Notes
  • D. A. Workman
    ORA Clinical Research and Development, North Andover, Massachusetts
  • G. W. Ousler, III
    ORA Clinical Research and Development, North Andover, Massachusetts
  • M. B. Abelson
    ORA Clinical Research and Development, North Andover, Massachusetts
    Harvard Medical School and Schepens Eye Research Institute, Boston, Massachusetts
  • Footnotes
    Commercial Relationships D.A. Workman, None; G.W. Ousler, None; M.B. Abelson, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 406. doi:
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      D. A. Workman, G. W. Ousler, III, M. B. Abelson; Age Related Differences in Lid Margin Health. Invest. Ophthalmol. Vis. Sci. 2007;48(13):406.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate the relationship between age and lid margin health.

 
Methods:
 

The lower lid margin and meibomian glands of seventy-four (74)subjects were evaluated. Subject photos were captured and graded.Subject photos were organized into seven age groups (0-18, 19-35,36-45, 46-55, 55-66, 67-77, and 78-92). Lid evaluation variablesconsisted of gland alignment, lid hyperkeratinization, lid vascularity,peri-gland redness, gland secretion color, gland height, cross-sectionalposterior lid margin, and lash misdirection.

 
Results:
 

Positive correlations exist between age and gland alignment(r=0.82, p=0.0001), lid hyperkeratinization (r=0.75, p=0.0001),lid vascularity (r=0.67, p=0.0001), gland secretion color (r=0.75,p=0.0001), cross-sectional posterior lid margin (r=0.793, p=0.0001),and lash misdirection (r=0.80, p=0.0001). Significance betweengroup differences were observed for gland alignment (F=27.92,p=0.009), lid hyperkeratinization (F=20.66, p=0.0001), lid vascularity(F=12.92, p=0.0001}, gland secretion color (F=17.61, p=0.0001),cross-sectional posterior lid margin (F=22.59, p=0.0001), andlash misdirection (F=20.81, p=0.0001). The following table showsage-sorted mean gland alignment, lid hyperkeratinization, lidvascularity, peri-gland redness, gland secretion color, cross-sectionalposterior lid margin, and lash misdirection. 

 

 
Conclusions:
 

The data demonstrates that increasing severity of lid margindisease is positively correlated with age. These lid marginchanges appear to be of chronic inflammatory nature.

 
Keywords: cornea: tears/tear film/dry eye • aging • cornea: clinical science 
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