May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Age Related Differences in Lid Margin Health
Author Affiliations & Notes
  • D. A. Workman
    ORA Clinical Research and Development, North Andover, Massachusetts
  • G. W. Ousler, III
    ORA Clinical Research and Development, North Andover, Massachusetts
  • M. B. Abelson
    ORA Clinical Research and Development, North Andover, Massachusetts
    Harvard Medical School and Schepens Eye Research Institute, Boston, Massachusetts
  • Footnotes
    Commercial Relationships D.A. Workman, None; G.W. Ousler, None; M.B. Abelson, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 406. doi:
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      D. A. Workman, G. W. Ousler, III, M. B. Abelson; Age Related Differences in Lid Margin Health. Invest. Ophthalmol. Vis. Sci. 2007;48(13):406.

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      © ARVO (1962-2015); The Authors (2016-present)

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To evaluate the relationship between age and lid margin health.


The lower lid margin and meibomian glands of seventy-four (74)subjects were evaluated. Subject photos were captured and graded.Subject photos were organized into seven age groups (0-18, 19-35,36-45, 46-55, 55-66, 67-77, and 78-92). Lid evaluation variablesconsisted of gland alignment, lid hyperkeratinization, lid vascularity,peri-gland redness, gland secretion color, gland height, cross-sectionalposterior lid margin, and lash misdirection.


Positive correlations exist between age and gland alignment(r=0.82, p=0.0001), lid hyperkeratinization (r=0.75, p=0.0001),lid vascularity (r=0.67, p=0.0001), gland secretion color (r=0.75,p=0.0001), cross-sectional posterior lid margin (r=0.793, p=0.0001),and lash misdirection (r=0.80, p=0.0001). Significance betweengroup differences were observed for gland alignment (F=27.92,p=0.009), lid hyperkeratinization (F=20.66, p=0.0001), lid vascularity(F=12.92, p=0.0001}, gland secretion color (F=17.61, p=0.0001),cross-sectional posterior lid margin (F=22.59, p=0.0001), andlash misdirection (F=20.81, p=0.0001). The following table showsage-sorted mean gland alignment, lid hyperkeratinization, lidvascularity, peri-gland redness, gland secretion color, cross-sectionalposterior lid margin, and lash misdirection. 



The data demonstrates that increasing severity of lid margindisease is positively correlated with age. These lid marginchanges appear to be of chronic inflammatory nature.

Keywords: cornea: tears/tear film/dry eye • aging • cornea: clinical science 

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