May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
A Correlation Between Central Corneal Staining and Visual Function in Patients Diagnosed With Dry Eye
Author Affiliations & Notes
  • G. W. Ousler, III
    ORA Clinical Research & Development, North Andover, Massachusetts
  • K. Brazzell
    Inspire Pharmaceuticals, Durham, North Carolina
  • T. Durham
    Inspire Pharmaceuticals, Durham, North Carolina
  • P. Walker
    ORA Clinical Research & Development, North Andover, Massachusetts
  • R. T. Anderson
    ORA Clinical Research & Development, North Andover, Massachusetts
  • M. B. Abelson
    ORA Clinical Research & Development, North Andover, Massachusetts
    Harvard Medical School and Schepens Eye Research Institute, Boston, Massachusetts
  • Footnotes
    Commercial Relationships G.W. Ousler, None; K. Brazzell, None; T. Durham, None; P. Walker, None; R.T. Anderson, None; M.B. Abelson, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 410. doi:
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    • Get Citation

      G. W. Ousler, III, K. Brazzell, T. Durham, P. Walker, R. T. Anderson, M. B. Abelson; A Correlation Between Central Corneal Staining and Visual Function in Patients Diagnosed With Dry Eye. Invest. Ophthalmol. Vis. Sci. 2007;48(13):410.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

The cornea is a unique and complex tissue that refracts and transmits light to the lens and retina while providing protection for inner ocular structures. The central 5 mm of the cornea and pre-corneal tear film account for at least two-thirds of the refractive power of the human visual system. This study was designed to investigate impairment of visual function consistent with central corneal staining.

 
Methods:
 

One hundred and six (106) eyes were evaluated: 54 eyes with central corneal staining and 52 control eyes with no central staining (central corneal staining scores of 0). Outcome measures included tear film break up time, fluorescein staining, and a series of visual function tasks including the inter-blink interval visual acuity decay (IVAD), reading rates, glare test, and BCVA (ETDRS). Patients also completed the Ocular Surface Disease Index (OSDI).

 
Results:
 

Patients with central corneal staining maintained their BCVA for a shorter amount of time (M=6.23sec, SD=4.31sec) during an extended inter-blink interval (without ocular anesthetic) than those without central staining (M=9.20sec, SD=8.91sec) as measured by the IVAD, p=.026. Patients with central staining also had longer reading rates (M=12.60sec, SD=4.51sec) than those without central staining (M=10.21sec, SD=3.04sec), p=.02. Data from the questionnaire measures demonstrated that patients without central staining had higher scores on the OSDI (M=6.73, SD=4.62) than those with central staining (M=4.47, SD=3.09), p=.006.  

 
Conclusions:
 

This data shows that dry eyes with central corneal staining have more profound visual function deficits than those without central corneal staining.

 
Keywords: cornea: epithelium • visual acuity • cornea: tears/tear film/dry eye 
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