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L. Kagemann, Jr., K. A. Townsend, G. Wollstein, T. Mumcuoglu, R. A. Bilonick, H. Ishikawa, M. L. Gabriele, J. G. Fujimoto, J. S. Duker, J. S. Schuman; Reproducibility of High Speed High Resolution Optical Coherence Tomography Retinal Nerve Fiber Layer Thickness Measurements. Invest. Ophthalmol. Vis. Sci. 2007;48(13):515.
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© ARVO (1962-2015); The Authors (2016-present)
The RTVue (Optovue, Fremont, CA) is a high speed high resolution optical coherence tomography (hsHR-OCT) device that acquires 25,000 A-scans/second with 5-6 micron axial resolution. The purpose of this study was to compare the reproducibility of retinal nerve fiber layer (RNFL) measurements made by RTVue, with those made by Stratus OCT (Carl Zeiss Meditec, Dublin, CA).
Eleven healthy and 17 glaucomatous eyes of 11 healthy and 11 glaucoma subjects were scanned with the RTVue NHM4 scan pattern and the Stratus OCT fast RNFL scan at the same visit. The NHM4 scan consists of 6 concentric circumpapillary scans with diameters from 2 to 4mm overlaid with 12 radial scans of diameter 3.4mm. All subjects had 3 good quality scans acquired during each visit. Healthy subjects had 3 visits and glaucoma patients had 2 visits within 2 months. Standard deviation (SD) and intraclass correlation coefficients (ICC) were calculated for overall average RNFL thickness and quadrant RNFL thickness measurements.
Stratus OCT had higher ICC’s for every intervisit and intravisit parameter. StratusOCT had lower SD’s for all but nasal quadrant intervisit RNFL thickness. Further RTVue segmentation algorithm refinement may improve reproducibility.
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