May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Reproducibility of High Speed High Resolution Optical Coherence Tomography Retinal Nerve Fiber Layer Thickness Measurements
Author Affiliations & Notes
  • L. Kagemann, Jr.
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
    Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • K. A. Townsend
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
  • T. Mumcuoglu
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
    Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
  • J. G. Fujimoto
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Duker
    Ophthalmology, New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania
    Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships L. Kagemann, None; K.A. Townsend, None; G. Wollstein, Carl Zeiss Meditec, Inc., R; T. Mumcuoglu, None; R.A. Bilonick, None; H. Ishikawa, Carl Zeiss Meditec, Inc., R; M.L. Gabriele, None; J.G. Fujimoto, Carl Zeiss Meditec, Inc., P; J.S. Duker, None; J.S. Schuman, Alcon, Carl Zeiss Meditec, Inc; Heidelberg Engineering, Allergan, Merck, Optovue, F; Carl Zeiss Meditec, Inc., P; Alcon, Allergan, Carl Zeiss Meditec, Inc; Heidelberg Engineering, Merck, Clarity, R.
  • Footnotes
    Support NIH EY13178, EY11289, EY08098, EY13078; NSF ECS-0119452, BES-0522845; AFOSR, FA9550-040-1-0011; MFEL FA9550-040-1-0046; Eye and Ear Foundation (Pittsburgh, PA), Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 515. doi:
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    • Get Citation

      L. Kagemann, Jr., K. A. Townsend, G. Wollstein, T. Mumcuoglu, R. A. Bilonick, H. Ishikawa, M. L. Gabriele, J. G. Fujimoto, J. S. Duker, J. S. Schuman; Reproducibility of High Speed High Resolution Optical Coherence Tomography Retinal Nerve Fiber Layer Thickness Measurements. Invest. Ophthalmol. Vis. Sci. 2007;48(13):515.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

The RTVue (Optovue, Fremont, CA) is a high speed high resolution optical coherence tomography (hsHR-OCT) device that acquires 25,000 A-scans/second with 5-6 micron axial resolution. The purpose of this study was to compare the reproducibility of retinal nerve fiber layer (RNFL) measurements made by RTVue, with those made by Stratus OCT (Carl Zeiss Meditec, Dublin, CA).

 
Methods:
 

Eleven healthy and 17 glaucomatous eyes of 11 healthy and 11 glaucoma subjects were scanned with the RTVue NHM4 scan pattern and the Stratus OCT fast RNFL scan at the same visit. The NHM4 scan consists of 6 concentric circumpapillary scans with diameters from 2 to 4mm overlaid with 12 radial scans of diameter 3.4mm. All subjects had 3 good quality scans acquired during each visit. Healthy subjects had 3 visits and glaucoma patients had 2 visits within 2 months. Standard deviation (SD) and intraclass correlation coefficients (ICC) were calculated for overall average RNFL thickness and quadrant RNFL thickness measurements.

 
Results:
 

 

 
Conclusions:
 

Stratus OCT had higher ICC’s for every intervisit and intravisit parameter. StratusOCT had lower SD’s for all but nasal quadrant intervisit RNFL thickness. Further RTVue segmentation algorithm refinement may improve reproducibility.

 
Clinical Trial:
 

www.clinicaltrials.gov NCT00343746

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • optic disc 
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