May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Recovery From Axial Myopia Induced by a Monocularly-Deprived Facemask in Adolescent (7-Week Old) Guinea Pigs
Author Affiliations & Notes
  • X. Zhou
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • F. Lu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • R. Xie
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • L. Jiang
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • J. Wen
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • Y. Li
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • J. Shi
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • J. Qu
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou Zhejiang, China
  • Footnotes
    Commercial Relationships X. Zhou, None; F. Lu, None; R. Xie, None; L. Jiang, None; J. Wen, None; Y. Li, None; J. Shi, None; J. Qu, None.
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1030. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      X. Zhou, F. Lu, R. Xie, L. Jiang, J. Wen, Y. Li, J. Shi, J. Qu; Recovery From Axial Myopia Induced by a Monocularly-Deprived Facemask in Adolescent (7-Week Old) Guinea Pigs. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1030. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: Guinea pigs have been increasingly used as an animal model for experimental myopia. Infant guinea pigs are susceptible to recovery from myopia within 2 weeks of form deprivation. This study investigated whether adolescent guinea pigs are susceptible to recovery from myopia after a longer period of form deprivation.

Methods:: Twenty-two guinea pigs (age of 3 weeks) were randomly assigned to 2 groups: MDF (monocularly-deprived facemask, n = 11) and normal control (free of form deprivation, n = 11). All animals underwent biometric measurement (refraction, corneal curvature and axial length) prior to the experiment. Animals in the MDF group wore a facemask that covered the right eye for 4 weeks. The MDF was then removed and biometric measurement was performed immediately and at 2, 6, 10 and 14 days. The same measurement was performed in the normal control group at time-points matching those of the MDF group.

Results:: The MDF eyes were approximately 4 D more myopic with a greater increase in vitreous length by 0.12 mm compared to either the fellow or the normal control eyes after form deprivation (p < 0.01). This relative myopia shifted rapidly towards hyperopia within 2 days after removal of the MDF, followed by a more steady recovery. A complete recovery occurred by 6 days after removal of the MDF compared to the fellow and normal control eyes (p > 0.05). Vitreous length in the MDF eyes slightly reduced within 2 days after removal of the MDF and then remained steady. The MDF eyes were similar to both the fellow and normal control eyes in vitreous length (p > 0.05) 6 days after removal of the MDF. There was no significant difference between the MDF, fellow and normal control eyes in the other axial components during the form deprivation and recovery period.

Conclusions:: Adolescent guinea pigs are susceptible to recovery from MDF-induced myopia. The refractive recovery is mainly correlated to the inhibited axial elongation of the vitreous chamber of the previously-deprived eyes.

Keywords: myopia • anatomy • refractive error development 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×